Intraoperative Corneal Thickness Monitoring During Corneal Collagen Cross-Linking With Isotonic Riboflavin Solution With and Without Dextran

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dc.contributor.authorOltulu, Refik
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorDonbaloglu, Meryem
dc.contributor.authorKerimoglu, Hurkan
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorKaraibrahimoglu, Adnan
dc.date.accessioned2024-02-23T14:21:10Z
dc.date.available2024-02-23T14:21:10Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractPurpose: The aim of this study was to analyze and compare corneal thickness changes during corneal collagen cross-linking procedures performed with isoosmolar riboflavin solution with 20% dextran and without dextran in corneal ectatic diseases. Methods: The patients in this study were analyzed in 2 groups: group 1 receiving riboflavin solution containing 20% dextran and group 2 receiving dextran-free riboflavin solution. Corneal thickness measurements were obtained with ultrasonic pachymetry at 6 different time points: preoperatively and at 0, 15, 30, 45, and 60 minutes after epithelial removal and initiation of ultraviolet A irradiation. Results: Twenty-seven eyes of 27 patients with progressive keratoconus were included in the study. In group 1 (n = 13), the mean preoperative thinnest pachymetric readings were 469.3 +/- 8.5 mu m, which decreased to 423.8 +/- 8.9 mu m after deepithelization and further decreased to 385.9 +/- 10.9 mm at 15 minutes. The corneal thickness assumed a steady course at the 30-, 45-, and 60-minute measurements (378.9 +/- 9.8 mu m, 384.5 +/- 10.5 mu m, and 396.7 +/- 9.4 mu m, respectively). The initial change was statistically significant (P < 0.01). In group 2 (n = 14), the corneal thickness decreased from 459.4 +/- 3.8 mu m to 414.7 +/- 2.6 mu m with deepithelization, after which it increased steadily with the initiation of the dextran-free riboflavin solution. The final measurement in group 2 was 474.1 +/- 9.4 mu mm; the increase at each time point was statistically significant when compared with the previous measurement (P < 0.01). Conclusions: Using isoosmolar riboflavin solution without dextran causes a steady increase in the corneal thickness during the cross-linking procedure, as opposed to riboflavin with dextran. This result might be beneficial in broadening the spectrum of cross-linking indications in patients with thin corneas.en_US
dc.identifier.doi10.1097/ICO.0000000000000249
dc.identifier.endpage1167en_US
dc.identifier.issn0277-3740
dc.identifier.issn1536-4798
dc.identifier.issue11en_US
dc.identifier.pmid25211359en_US
dc.identifier.scopus2-s2.0-84926099796en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1164en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000000249
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13463
dc.identifier.volume33en_US
dc.identifier.wosWOS:000343672300007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeratoconusen_US
dc.subjectCollagen Cross-Linkingen_US
dc.subjectCorneal Thicknessen_US
dc.titleIntraoperative Corneal Thickness Monitoring During Corneal Collagen Cross-Linking With Isotonic Riboflavin Solution With and Without Dextranen_US
dc.typeArticleen_US

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