Renal Drug Dosage Adjustment According to Estimated Creatinine Clearance in Hospitalized Patients With Heart Failure

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dc.contributor.authorAltunbas, Gokhan
dc.contributor.authorYazici, Mehmet
dc.contributor.authorSolak, Yalcin
dc.contributor.authorGul, Enes E.
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorKaya, Zeynettin
dc.contributor.authorAkilli, Hakan
dc.date.accessioned2024-02-23T14:21:04Z
dc.date.available2024-02-23T14:21:04Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractIt is of clinical importance to determine creatinine clearance and adjust doses of prescribed drugs accordingly in patients with heart failure to prevent untoward effects. There is a scarcity of studies in the literature investigating this issue particularly in patients with heart failure, in whom many have impaired kidney function. The purpose of this study was to determine the degree of awareness of medication prescription as to creatinine clearance in patients hospitalized with heart failure. Patients hospitalized with a diagnosis of heart failure were retrospectively evaluated. Among screened charts, patients with left ventricular ejection fraction,40% and an estimated glomerular filtration rate (eGFR) of <= 50 mL/min were included in the analysis. The medications and respective doses prescribed at discharge were recorded. Medications requiring renal dose adjustment were determined and evaluated for appropriate dosing according to eGFR. A total of 388 patients with concomitant heart failure and renal dysfunction were included in the study. The total number of prescribed medications was 2808 and 48.3% (1357 medications) required renal dose adjustment. Of the 1357 medications, 12.6% (171 medications) were found to be inappropriately prescribed according to eGFR. The most common inappropriately prescribed medications were famotidine, metformin, perindopril, and ramipril. A significant portion of medications used in heart failure requires dose adjustment. Our results showed that in a typical cohort of patients with heart failure, many drugs are prescribed at inappropriately high doses according to creatinine clearance. Awareness should be increased among physicians caring for patients with heart failure to prevent adverse events related to medications.en_US
dc.description.sponsorshipERA-EDTAen_US
dc.description.sponsorshipDr. A. Gaipov received grant support from the ERA-EDTA fellowship program.en_US
dc.identifier.doi10.1097/01.mjt.0000434042.62372.49
dc.identifier.endpageE1008en_US
dc.identifier.issn1075-2765
dc.identifier.issn1536-3686
dc.identifier.issue4en_US
dc.identifier.pmid24263162en_US
dc.identifier.scopus2-s2.0-84887932257en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE1004en_US
dc.identifier.urihttps://doi.org/10.1097/01.mjt.0000434042.62372.49
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13434
dc.identifier.volume23en_US
dc.identifier.wosWOS:000379663800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal Of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Dose Adjustmenten_US
dc.subjectHeart Failureen_US
dc.subjectRenal Failureen_US
dc.subjectPolypharmacyen_US
dc.titleRenal Drug Dosage Adjustment According to Estimated Creatinine Clearance in Hospitalized Patients With Heart Failureen_US
dc.typeArticleen_US

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