The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity

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dc.contributor.authorDoseyici, S.
dc.contributor.authorMehmetoglu, I.
dc.contributor.authorToker, A.
dc.contributor.authorYerlikaya, F. H.
dc.contributor.authorErbay, E.
dc.date.accessioned2024-02-23T14:34:37Z
dc.date.available2024-02-23T14:34:37Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObesity is a major health problem. We investigated the effects of forskolin and rolipram in the diet of animals in which obesity had been induced. We used 50 female albino Wistar rats that were assigned randomly into five groups as follows: group 1, control; group 2, high fat diet; group 3, high fat diet + forskolin; group 4, high fat diet + rolipram; and group 5, high fat diet + rolipram + forskolin. The rats were fed for 10 weeks and rolipram and forskolin were administered during last two weeks. The animals were sacrificed and blood samples were obtained. Serum cAMP, cGMP and free fatty acids (FFA) levels were measured using ELISA assays. We also measured weight gain during the 10 week period. cAMP and FFA levels of groups 3, 4 and 5 were significantly higher than those of groups 1 and 2. We found no significant differences in serum cGMP levels among the groups. The weight gain in groups 3, 4 and 5 was significantly less than for group 2. We also found that the weight gain in group 5 was significantly less than in groups 3 and 4. We found that both forskolin and rolipram stimulated lipolysis and inhibited body weight increase by increasing cAMP levels. Also, combination therapy using the two agents may be more effective in preventing diet induced obesity than either agent alone. We found also that these agents did not effect cellular cGMP levels in diet induced obesity.en_US
dc.identifier.doi10.3109/10520295.2014.883463
dc.identifier.endpage392en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid24520882en_US
dc.identifier.scopus2-s2.0-84902796150en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2014.883463
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15674
dc.identifier.volume89en_US
dc.identifier.wosWOS:000337900500009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCampen_US
dc.subjectCgmpen_US
dc.subjectFatty Acidesen_US
dc.subjectDieten_US
dc.subjectForskolinen_US
dc.subjectObesityen_US
dc.subjectRolipramen_US
dc.titleThe effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesityen_US
dc.typeArticleen_US

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