Neutrophil lymphocyte ratio, mean platelet volume, and immunoreactive trypsinogen as early inflammatory biomarkers for cystic fibrosis in infancy: A retrospective cohort study

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dc.contributor.authorEyuboglu, Tugba Sismanlar
dc.contributor.authorAslan, Ayse Tana
dc.contributor.authorAsfuroglu, Pelin
dc.contributor.authorKunt, Nursima
dc.contributor.authorErsoy, Ali
dc.contributor.authorKose, Mehmet
dc.contributor.authorUnal, Gokcen
dc.date.accessioned2024-02-23T13:03:31Z
dc.date.available2024-02-23T13:03:31Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackgroundAirway inflammation starts in early life in cystic fibrosis (CF) and limited, objective markers are available to help identify infants with increased inflammation. We aimed to investigate neutrophil, lymphocyte ratio (NLR), mean platelet volume (MPV) and immunoreactive trypsinogen (IRT) to be a possible inflammatory biomarker for CF in infancy. MethodsThis was a retrospective cohort study in three centers. Between January 2015 and December 2022, children with CF newborn screening (NBS) positivity and diagnosed as CF were included in the study. Correlation analysis were performed with NLR, MPV, IRT and follow-up parameters such as z-scores, modified Shwachman-Kulczycki score (mSKS) at the first, second, third and sixth ages and pulmonary function test (PFT) at the sixth age. ResultsA total of 92 children with CF included in the study and 47.8% of them were female. There were no correlations between NLR, MPV and weight and height z-scores for all ages (p > 0.05), a negative correlation was found between MPV and body mass indexes (BMI) z-score at the age of 6 (r = -0.443, p = 0.038). No correlation was found between NLR, MPV and PFT parameters and mSKS at all ages (p > 0.05). There was a negative correlation between first IRT and BMI z-score at 6 years of age (r = -0.381, p = 0.046) and negative correlations between second IRT and weight and BMI z-score at the age of 6 (r = -0.462, p = 0.010; r = -0.437, p = 0.016, respectively). ConclusionHigher MPV and IRT levels during NBS period are associated with worse nutritional outcome which may reflect chronic inflammation. Children with higher MPV and IRT should be followed up closely in terms of chronic inflammation and nutritional status.en_US
dc.identifier.doi10.1002/ppul.26628
dc.identifier.endpage3112en_US
dc.identifier.issn8755-6863
dc.identifier.issn1099-0496
dc.identifier.issue11en_US
dc.identifier.pmid37530491en_US
dc.identifier.scopus2-s2.0-85166635469en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3106en_US
dc.identifier.urihttps://doi.org/10.1002/ppul.26628
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10657
dc.identifier.volume58en_US
dc.identifier.wosWOS:001041095400001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectCystic Fibrosisen_US
dc.subjectInfancyen_US
dc.subjectInflammationen_US
dc.titleNeutrophil lymphocyte ratio, mean platelet volume, and immunoreactive trypsinogen as early inflammatory biomarkers for cystic fibrosis in infancy: A retrospective cohort studyen_US
dc.typeArticleen_US

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