Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder

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dc.contributor.authorFerahkaya, Hursit
dc.contributor.authorAkca, Omer Faruk
dc.contributor.authorBaysal, Tamer
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T14:02:45Z
dc.date.available2024-02-23T14:02:45Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractBackground and objectives: Accumulating studies have pointed out that gut-blood and blood -brain barrier dysfunctions due to the alterations in permeability may play a role in the patho-physiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, occludin, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.Methods: A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.Results: Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.Conclusion: These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.(c) 2023 Sociedad Espanola de Psiquiatna y Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipNec-mettin Erbakan University Scientific Research Projects Unit [201518024]en_US
dc.description.sponsorshipFunding for this study was provided by a grant from the Nec-mettin Erbakan University Scientific Research Projects Unit within the scope of project number 201518024.en_US
dc.identifier.doi10.1016/j.ejpsy.2023.100225
dc.identifier.issn0213-6163
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85175198021en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpsy.2023.100225
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11837
dc.identifier.volume38en_US
dc.identifier.wosWOS:001089218400001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofEuropean Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhden_US
dc.subjectBlood -Brain Barrieren_US
dc.subjectClaudin-5en_US
dc.subjectGut -Brain Axisen_US
dc.subjectMicrobiotaen_US
dc.subjectTricellulinen_US
dc.titleClaudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorderen_US
dc.typeArticleen_US

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