Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors

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dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorYavuz, Berrin Benli
dc.contributor.authorAktan, Meryem
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorUyar, Mehmet
dc.contributor.authorFindik, Siddika
dc.date.accessioned2024-02-23T14:41:04Z
dc.date.available2024-02-23T14:41:04Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective: The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factors in breast cancer patients. Materials and Methods: Between 2010 and 2017, patients with invasive ductal carcinoma who received radiotherapy after surgery were included in study. A single pathologist re-defined of all cases retrospectively. Ki-67 were established three categories based on Ki-67 levels: low (<10%), intermediate (10-25%) and high (>25%). Results: A total of 258 patients were included. 46 of 258 (18%) patients were in low, 82 of 258 (32%) patients were in intermediate and 130 of 258 (50%) patients were in high Ki-67 group. There were no correlations between menopausal status, age, and Ki-67 level. Low-pT stages tended to have low Ki-67 expression (p=0.07). Low-pN stages correlated with low Ki-67 values (p=0.007). Patients with ECE (+) were prone to have higher Ki-67 values (p=0.02). The significant correlation was seen between Ki-67 and tumour grading (p=<0.0001). Patients with LVI (+) had higher Ki-67 expression (p=0.007). Luminal A tumours were correlated with low Ki-67 group (p=<0.0001). Ki-67 values had significant effect on DFS (p=0.03) but not OS (p=0.09). Conclusion: This study showed that high Ki-67 expression is associated with higher pT-stage, higher pN-stage, higher grade, ER/PR negativity, HER2/neu positivity, ECE and LVI positivity. The prognostic impact of Ki-67 was only demonstrated for DFS.en_US
dc.identifier.doi10.5152/ejbh.2019.4778
dc.identifier.endpage261en_US
dc.identifier.issn2587-0831
dc.identifier.issue4en_US
dc.identifier.pmid31620685en_US
dc.identifier.scopus2-s2.0-85083322149en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://doi.org/10.5152/ejbh.2019.4778
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16694
dc.identifier.volume15en_US
dc.identifier.wosWOS:000488785600009en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofEuropean Journal Of Breast Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Canceren_US
dc.subjectKi-67en_US
dc.subjectPrognostic Factorsen_US
dc.subjectRadiotherapyen_US
dc.subjectSurvivalen_US
dc.titlePrognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factorsen_US
dc.typeArticleen_US

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