Comparison of embryo morphokinetics following intracytoplasmic sperm injection in smoker and non-smoker couples: Are the results different?

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dc.contributor.authorSalvarci, Ahmet
dc.contributor.authorGurbuz, Ali Sami
dc.contributor.authorUzman, Sukru
dc.contributor.authorKaya, Melek
dc.contributor.authorGorkemli, Huseyin
dc.date.accessioned2024-02-23T14:48:59Z
dc.date.available2024-02-23T14:48:59Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractObjective: To assess early embryo development via time-lapse in smokers and non-smokers. Methods: The retrospective study was conducted at Novafertil IVF centers in Konya, Turkey and comprised oocytes of both smoker and non-smoker couples subjected to in vitro fertilisation /introcytoplasmic sperm injection from 2012 to 2015. Age, basal follicle-stimulating hormone, number of stimulation days, amount of gonadotropin used, number of metaphase II oocytes, number of embryos transferred and pregnancy, abortus and clinical pregnancy rates were noted. The embryos were observed for 72 hours in the time-lapse monitoring system. SPSS 22 was used for data analysis. Results: Of the 257 couples, 132(51.4%) were non-smokers and 125(48.6%) were smokers. A total of 1,414 oocytes were collected from non-smokers and 1,280 oocytes from smokers. There was no significant difference in the age of patients and number of stimulation days between the smoker and non-smoker groups (p>0.05). The number of oocytes, fertilised oocytes, transferred embryos and metaphase II oocytes was significantly less in the smoker group (p<0.05). The rate of pregnancy and ongoing pregnancy was also lower in the smoker group (p<0.05)smoker and non-smoker groups (p<0.05). A prolongation was observed in time to pronuclear fading. A difference was observed in time of pronuclei appearance, t8, t9+ cleavage times in time-lapse in the and t2 cleavage times in time-lapse in the non-smoker group (p<0.05). Some chromosomal number and structural defects were identified in preimplantation genetic in some embryos with prolongation in time-lapse cleavage time in the smoker and nonsmoker groups. Conclusion: The negative impacts of smoking were not observed at each cleavage phase of embryo development in time-lapse.en_US
dc.identifier.endpage1557en_US
dc.identifier.issn0030-9982
dc.identifier.issue10en_US
dc.identifier.pmid28955073en_US
dc.identifier.scopus2-s2.0-85029152404en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1552en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17941
dc.identifier.volume67en_US
dc.identifier.wosWOS:000417996100017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal Of The Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEmbryoen_US
dc.subjectTime-Lapseen_US
dc.subjectEmbryoscopeen_US
dc.subjectSmokeen_US
dc.subjectSpermen_US
dc.subjectIcsien_US
dc.subjectPgten_US
dc.titleComparison of embryo morphokinetics following intracytoplasmic sperm injection in smoker and non-smoker couples: Are the results different?en_US
dc.typeArticleen_US

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