Relationship between Selective IgA Deficiency and COVID-19 Prognosis

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dc.contributor.authorColkesen, Fatih
dc.contributor.authorKandemir, Bahar
dc.contributor.authorArslan, Sevket
dc.contributor.authorColkesen, Fatma
dc.contributor.authorYildiz, Eray
dc.contributor.authorKorkmaz, Celalettin
dc.contributor.authorVatansev, Hulya
dc.date.accessioned2024-02-23T14:44:57Z
dc.date.available2024-02-23T14:44:57Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe prevalence and mortality rates of coronavirus disease 2019 (COVID-19) widely vary among populations. Mucosal immunity is the first barrier to the pathogen's entry into the body. Immunoglobulin A (IgA) is the primary antibody responsible for mucosal immunity. We explored the relationship between selective IgA deficiency (SIgAD) and COVID-19 severity. We included 424 patients (203 women) with COVID-19. Eleven patients had SIgAD. Laboratory data of patients with SIgAD and normal IgA levels were compared. The relationship between SIgAD and severe COVID-19 infection was explored using logistic regression analysis. In the univariate logistic regression analysis, the risk of severe COVID-19 disease in patients with SIgAD was approximately 7.7 -fold higher than that in other patients (odds ratio [OR], 7.789; 95% confidence interval [CI], 1.665-36.690, P = 0.008), while it was 4-fold (OR, 4.053; 95% CI, 1.182-13.903, P = 0.026) higher in the multivariate logistic regression analysis. Serum IgA levels were positively correlated with total lymphocyte counts and negatively correlated with C-reactive protein levels, which was a risk factor for severe COVID-19. In patients with SIgAD, the number of severe acute respiratory coronaviruses 2 that pass through mucosal membranes may be increased, leading to complications such as cytokine storm syndrome and acute respiratory distress syndrome.en_US
dc.identifier.doi10.7883/yoken.JJID.2021.281
dc.identifier.endpage233en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue3en_US
dc.identifier.pmid34588364en_US
dc.identifier.scopus2-s2.0-85121231878en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://doi.org/10.7883/yoken.JJID.2021.281
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17162
dc.identifier.volume75en_US
dc.identifier.wosWOS:000821183900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatl Inst Infectious Diseasesen_US
dc.relation.ispartofJapanese Journal Of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleRelationship between Selective IgA Deficiency and COVID-19 Prognosisen_US
dc.typeArticleen_US

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