Anticancer, antidiabetic, and antioxidant activities of endemic Stachys buttleri Mill. and Stachys pinardii Boiss. essential oils

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dc.contributor.authorUestuener, Hatice
dc.contributor.authorBarak, Timur Hakan
dc.contributor.authorServi, Hueseyin
dc.contributor.authorErtekin, Simge Kara
dc.contributor.authorSen, Ali
dc.contributor.authorDinc, Muhittin
dc.contributor.authorOezkan, Vedat Kadir
dc.date.accessioned2024-02-23T14:20:22Z
dc.date.available2024-02-23T14:20:22Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThere are numerous species in genus Stachys which are known for valuable and bioactive essential oils. For this study, essential oils of Stachys buttleri (SBE) and S. pinardii (SPE) were obtained by hydrodistillation method and the chemical composition of essential oils were determined by GC-MS analysis. Anticancer, antidiabetic, and antioxidant activities of essential oils were tested by MTT assay, alpha-glucosidase inhibitory, and ABTS radical scavenging methods, respectively. Forty-one compounds were determined in SBE (83.5%) which kolavelool (34.9%) was the main compound and diterpenoids (61.2%) were the dominant group of SBE. Thirty-three constituents were identified in SPE (90.6%) and trans-nerolidol (35.7%) and geranyl-alpha-terpinene (17.2%) were the most abundant compounds. SPE was characterized by its high proportion of oxygenated sesquiterpenes (39.1%), diterpenoids (21.4%), aromatics (14.8%), and sesquiterpenes (10.8%). Both essential oils showed strong anticancer activity against A549, U87MG, Ishikawa, and MCF-7 cell lines. These results indicated that SBE and SPE had potent anticancer activity. The IC50 values of essential oils were between 21.33-98.3 mu g/mL. Both essential oils showed moderate antioxidant and antidiabetic activities. This study is the first report on the chemical composition and biological activities of the essential oils of S. buttleri and S. pinardii.en_US
dc.identifier.doi10.1080/0972060X.2023.2293960
dc.identifier.endpage1514en_US
dc.identifier.issn0972-060X
dc.identifier.issn0976-5026
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85181211099en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1502en_US
dc.identifier.urihttps://doi.org/10.1080/0972060X.2023.2293960
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13140
dc.identifier.volume26en_US
dc.identifier.wosWOS:001133407100011en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Essential Oil Bearing Plantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStachys Buttlerien_US
dc.subjectStachys Pinardiien_US
dc.subjectEssential Oilen_US
dc.subjectAnticanceren_US
dc.subjectAntidiabeticen_US
dc.subjectAntioxidanten_US
dc.subjectGc-Msen_US
dc.titleAnticancer, antidiabetic, and antioxidant activities of endemic Stachys buttleri Mill. and Stachys pinardii Boiss. essential oilsen_US
dc.typeArticleen_US

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