A Dicationic BODIPY-Based Fluorescent Bactericide to Combat Infectious Diseases and to Eradicate Bacterial Biofilms

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dc.contributor.authorKocak, Haluk Samet
dc.contributor.authorBulut, Onur
dc.contributor.authorYilmaz, M. Deniz
dc.date.accessioned2024-02-23T14:16:35Z
dc.date.available2024-02-23T14:16:35Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractIncreased bacterial resistance against extensively used common disinfectants has begun to emerge. The discovery of disinfectants substituting the current commercially available ones is strongly needed. For this purpose, a dicationic BODIPY-based fluorescent amphiphile has been synthesized by specific molecular design. This quaternized BODIPY behaves as a broad-spectrum disinfectant against both Gram-positive and Gram-negative bacteria strains. It exhibits potent antimicrobial activity against tested microorganisms when compared with structurally similar disinfectant benzalkonium chloride (BAC). Moreover, it shows antibiofilm activity against Staphylococcus epidermidis with a minimum biofilm eradication concentration as low as 16 mu g/mL. The interaction of this compound with the bacterial cell and genomic DNA was further evaluated by fluorescence spectroscopy and microscopy to follow cell internationalization and to clarify the mechanism of antibacterial action.en_US
dc.description.sponsorshipKonya Food and Agriculture University (KFAU)en_US
dc.description.sponsorshipWe would like to thank Konya Food and Agriculture University (KFAU) for their support of this research. We are also grateful to Mert Sudagidan, former R & D Lab Manager, for his generous donation of clinical S. epidermidis YT -169a isolates.en_US
dc.identifier.doi10.1021/acsabm.3c00021
dc.identifier.endpage1610en_US
dc.identifier.issn2576-6422
dc.identifier.issue4en_US
dc.identifier.pmid36917772en_US
dc.identifier.scopus2-s2.0-85150425610en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1604en_US
dc.identifier.urihttps://doi.org/10.1021/acsabm.3c00021
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12727
dc.identifier.volume6en_US
dc.identifier.wosWOS:000972547200001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Applied Bio Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial Resistanceen_US
dc.subjectBacterial Infectionsen_US
dc.subjectQuaternary Ammonium Compoundsen_US
dc.subjectBodipyen_US
dc.subjectFluorescenten_US
dc.titleA Dicationic BODIPY-Based Fluorescent Bactericide to Combat Infectious Diseases and to Eradicate Bacterial Biofilmsen_US
dc.typeArticleen_US

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