The relationship between plasma microRNAs and serum trace elements levels in primary hyperlipidemia

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dc.contributor.authorYerlikaya, F. H.
dc.contributor.authorCan, U.
dc.contributor.authorAlpaydin, M. S.
dc.contributor.authorAribas, A.
dc.date.accessioned2024-02-23T14:37:59Z
dc.date.available2024-02-23T14:37:59Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVES: The aim of the study was to investigate the relationship between plasma microRNA expression levels, which are associated with lipid metabolism and serum trace element levels in patients with primary hyperlipidemia. METHODS: This study was performed on 46 (21M / 25F) primary hyperlipidemia patients aged 25-65 years and 37 (18 M/19 F) healthy people aged 25-65 years. RESULTS: The following miRNAs were upregulated: miR-33a-5p, miR-370-5p, miR-378a-3p, miR-27a-3p, miR-27a-5p and miR-335-5p. Additionally, the levels of Co (p < 0.001), Ni (p < 0.01), Cd (p < 0.001) were significantly higher and the level of Cr (p < 0.01), Fe (p < 0.05), Mn (p < 0.01), Se (p < 0.001) and Mo (p < 0.001) was significantly lower in the primary hyperlipidemic patients compared to the healthy people. Also, miR-33a-5p was negatively correlated with serum Cr levels in patients with primary hyperlipidemia (r = -0.376, p < 0.05). CONCLUSIONS: Our study demonstrates that miR-33a-5p and Cr element may regulate abnormal lipid homeostasis. Also, miR-370, miR-378, miR-27-a and miR-335 might aid in the identification of new therapies to treat patients with primary hyperlipidemiaen_US
dc.description.sponsorshipUniversity of Necmettin Erbakan, Scientific Research Projects Department (BAP), Konya-Turkey [131218002]en_US
dc.description.sponsorshipThis research was supported by Grant 131218002 from University of Necmettin Erbakan, Scientific Research Projects Department (BAP), Konya-Turkey.en_US
dc.identifier.doi10.4149/BLL_2019_056
dc.identifier.endpage348en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid31113196en_US
dc.identifier.scopus2-s2.0-85066460654en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2019_056
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16321
dc.identifier.volume120en_US
dc.identifier.wosWOS:000468529200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary Hyperlipidemiaen_US
dc.subjectMicrornaen_US
dc.subjectTrace Elementsen_US
dc.titleThe relationship between plasma microRNAs and serum trace elements levels in primary hyperlipidemiaen_US
dc.typeArticleen_US

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