Sunitinib-induced small bowel wall edema as a prognostic marker in metastatic renal cell carcinoma

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dc.contributor.authorKorkmaz, Mustafa
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorKerimoglu, Ulku
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorKocak, Mehmet Zahid
dc.contributor.authorDemirkiran, Aykut
dc.contributor.authorAraz, Murat
dc.date.accessioned2024-02-23T14:37:53Z
dc.date.available2024-02-23T14:37:53Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractAim: The aim of this study was to evaluate the presence of small bowel wall edema (SBWE) on computed tomography (CT) images in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib and to investigate the relationship between the presence of SBWE and survival. Materials and Methods: We retrospectively evaluated the presence of SBWE on CT images of 27 mRCC patients who received at least one cycle of sunitinib. Then, we analyzed the relationship between the presence of SBWE and progression-free survival (PFS) and overall survival (OS). Results: All 27 patients had SBWE on at least one CT scan. The median value of SBWE thickness was 2.5 mm. SBWE thickness was <= 2.5 mm in 13 patients (group A) and >2.5 mm in 14 patients (group B). The median OS was significantly higher in group B (55 vs. 18 months, respectively, P = 0.02). Although it was not statistically significant (13 vs. 8 months, respectively, P = 0.69), the median PFS was longer in group B than in group A. Conclusions: This study showed that sunitinib treatment caused SBWE in all patients with mRCC who received the drug. Also, this study demonstrated an association between higher SBWE thickness and better survival outcomes.en_US
dc.identifier.doi10.4103/jcrt.jcrt_899_21
dc.identifier.endpage393en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue2en_US
dc.identifier.pmid37313914en_US
dc.identifier.scopus2-s2.0-85161897515en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage389en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.jcrt_899_21
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16258
dc.identifier.volume19en_US
dc.identifier.wosWOS:001107250300037en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiarrheaen_US
dc.subjectPrognostic Markeren_US
dc.subjectSmall Bowel Edemaen_US
dc.subjectSunitiniben_US
dc.titleSunitinib-induced small bowel wall edema as a prognostic marker in metastatic renal cell carcinomaen_US
dc.typeArticleen_US

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