Comparison of anti-TNF and IL-inhibitors treatments in patients with psoriasis in terms of response to routine laboratory parameter dynamics

Basit Öğe Kaydı
dc.contributor.authorAtaseven, Arzu
dc.contributor.authorTemiz, Selami Aykut
dc.contributor.authorEren, Gullu
dc.contributor.authorOzer, Ilkay
dc.contributor.authorDursun, Recep
dc.date.accessioned2024-02-23T14:20:19Z
dc.date.available2024-02-23T14:20:19Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground Biological agent treatments represent a relatively new field and their effects on routine laboratory parameters are not fully known as there has been little research in the area. In our study, we aimed to evaluate the differences between the two main biological treatment groups and their effects on routine laboratory parameters. Methods Patients were enrolled when they had received treatment for more than six months with biological treatments between January 2013 and April 2020. The available data on routine laboratory parameters were collected by routine blood tests before the treatment, at three months, and at the final evaluation. Results When the changes in routine laboratory parameters were evaluated by treatment, it was found that the NLR and CRP values decreased statistically significantly in the anti-TNF group compared to the IL inhibitor group. In addition, strong suppression of these inflammation parameters means strong suppression of the immune system response. In addition, AST, ALT, and creatinine values were found to be statistically significantly higher in the anti-TNF group compared to the IL inhibitor group. Conclusions In our study, anti-TNF treatments are shown to be more effective in reducing inflammation parameters while IL antagonists are safer in terms of biochemical parameters.en_US
dc.identifier.doi10.1080/09546634.2020.1801975
dc.identifier.endpage1096en_US
dc.identifier.issn0954-6634
dc.identifier.issn1471-1753
dc.identifier.issue2en_US
dc.identifier.pmid32713225en_US
dc.identifier.scopus2-s2.0-85089036111en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1091en_US
dc.identifier.urihttps://doi.org/10.1080/09546634.2020.1801975
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13117
dc.identifier.volume33en_US
dc.identifier.wosWOS:000555638500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Dermatological Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriasisen_US
dc.subjectBiologicsen_US
dc.subjectTnf Inhibitionen_US
dc.subjectIl-12-23 Inhibitionen_US
dc.subjectIl-17 Inhibitionen_US
dc.titleComparison of anti-TNF and IL-inhibitors treatments in patients with psoriasis in terms of response to routine laboratory parameter dynamicsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu