The Relationship between Oxidative Stress, Inflammation, and Atherosclerosis in Renal Transplant and End-Stage Renal Disease Patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorTonbul, Halil Zeki
dc.contributor.authorToker, Aysun
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorErdur, Fatih Mehmet
dc.contributor.authorCicekler, Humeyra
dc.contributor.authorAnil, Melih
dc.date.accessioned2024-02-23T14:34:36Z
dc.date.available2024-02-23T14:34:36Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractObjectives: Cardiovascular risk is increased in the early stages of chronic kidney disease (CKD) and is also found to be ongoing in renal transplant (Rtx) patients. As a sign of atherosclerosis, increased carotid intima-media thickness (CIMT) has been widely accepted as a strong predictor of cardiovascular disease (CVD) and mortality in the end-stage renal disease (ESRD) patients. Ischemia-modified albumin (IMA), pentraxin-3 (PTX-3), and neutrophil-to-lymphocyte ratio (NLR) were introduced as oxidative stress and inflammatory biomarkers in ESRD. The role of Rtx in terms of atherogenesis, oxidative stress, and inflammation is still unclear. We aimed to investigate the relationship between IMA, PTX-3, NLR, and CIMT in Rtx patients without overt CVD and to compare these results with those obtained from healthy subjects and ESRD patients receiving hemodialysis (HD) and peritoneal dialysis (PD). Design and methods: Cross-sectional analysis in which CIMT measurements, NLR, and serum PTX-3 and IMA levels were assessed in 18 Rtx patients (10 females; mean age: 40.0 +/- 13.3 years), 16 PD patients (7 females; 40.2 +/- 12.9 years), 14 HD patients (8 females; 46.6 +/- 10.7 years), and 19 healthy subjects (9 females; 36.9 +/- 8.9 years). Results: IMA, PTX-3, and high-sensitive C-reactive protein (hs-CRP) levels, NLR, and CIMT of Rtx patients were found to be significantly higher compared with healthy subjects (p = 0.04, p < 0.0001, p < 0.005, p = 0.005, and p = 0.005, respectively). IMA level was positively correlated with hs-CRP and PTX-3 levels, NLR, and CIMT when all participants were included (r = 0.338, p = 0.005; r 0.485, p < 0.0001; r = 0.304, p = 0.013; and r = 0.499, p < 0.0001, respectively). Conclusion: There has been ongoing inflammation, oxidative stress, and atherosclerosis in Rtx patients.en_US
dc.description.sponsorshipERA-EDTA fellowship programen_US
dc.description.sponsorshipDr. A. Gaipov received grant support from the ERA-EDTA fellowship program.en_US
dc.identifier.doi10.3109/0886022X.2012.723580
dc.identifier.endpage1237en_US
dc.identifier.issn0886-022X
dc.identifier.issue10en_US
dc.identifier.pmid23025491en_US
dc.identifier.scopus2-s2.0-84867705339en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1229en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2012.723580
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15659
dc.identifier.volume34en_US
dc.identifier.wosWOS:000310016300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectPentraxin-3en_US
dc.subjectNeutrophil-To-Lymphocyte Ratioen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectRenal Transplantationen_US
dc.subjectEnd-Stage Renal Diseaseen_US
dc.titleThe Relationship between Oxidative Stress, Inflammation, and Atherosclerosis in Renal Transplant and End-Stage Renal Disease Patientsen_US
dc.typeArticleen_US

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