Comparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal cancer

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dc.contributor.authorTasci, Elif Senocak
dc.contributor.authorOyan, Basak
dc.contributor.authorSoenmez, Oezlem
dc.contributor.authorMutlu, Arda Ulas
dc.contributor.authorAtci, Muhammed Mustafa
dc.contributor.authorSakin, Abdullah
dc.contributor.authorOener, Irem
dc.date.accessioned2024-02-23T14:27:18Z
dc.date.available2024-02-23T14:27:18Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractBackground The optimal treatment for metastatic colorectal cancer (mCRC) after the second line is still controversial. Regorafenib has been the standard of care in this setting as it improved overall survival (OS) compared to placebo. In real-world practice chemotherapy rechallenge is also a preferred option even though supporting evidence is not enough. We aim to compare the efficacy of regorafenib and 5-fluorouracil-based (5-FU) rechallenge treatment in the third line setting of mCRC.Methods In this retrospective multi-institutional trial, mCRC patients from 21 oncology centers who progressed after 2 lines of chemotherapy were analyzed. Patients who were treated with regorafenib or rechallenge therapy in the third-line setting were eligible. Rechallenge chemotherapy was identified as the re-use of the 5-FU based regimen which was administered in one of the previous treatment lines. OS, disease control rate (DCR), progression free survival (PFS) and toxicity were analyzed.Results Three hundred ninety-four mCRC patients were included in the study. 128 (32.5%) were in the rechallenge, and 266 (67.5%) were in the regorafenib group. Median PFS was 5.82 months in rechallenge and 4 months in regorafenib arms (hazard ratio:1.45,95% CI, p = 0.167). DCR was higher in the rechallenge group than regorafenib (77% vs 49.5%, respectively, p = < 0.001). Median OS after the third-line treatment was 11.99 (95% CI, 9.49-14.49) and 8.08 months (95% CI, 6.88-9.29) for rechallenge and regorafenib groups, respectively (hazard ratio:1.51, 95% CI, p < 0.001). More adverse effects and discontinuation were seen with regorafenib treatment.Conclusion Our study revealed that higher disease control and OS rates were achieved with rechallenge treatment compared to regorafenib, especially in patients who achieved disease control in one of the first two lines of therapy.en_US
dc.identifier.doi10.1186/s12885-023-11783-5
dc.identifier.issn1471-2407
dc.identifier.issue1en_US
dc.identifier.pmid38166764en_US
dc.identifier.scopus2-s2.0-85181247540en_US
dc.identifier.urihttps://doi.org/10.1186/s12885-023-11783-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14539
dc.identifier.volume24en_US
dc.identifier.wosWOS:001135401800028en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColon Canceren_US
dc.subjectFluouracilen_US
dc.subjectRechallengeen_US
dc.subjectRegorafeniben_US
dc.subjectSurvivalen_US
dc.subjectThird-Line Treatmenten_US
dc.titleComparing the efficacy of regorafenib and 5-fluorouracil-based rechallenge chemotherapy in the third-line treatment of metastatic colorectal canceren_US
dc.typeArticleen_US

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