Antibacterial potentials of carbon dots immobilized on chitosan and glass surfaces

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dc.contributor.authorGhaibullah, Yanar Najmalden Ghaibullah
dc.contributor.authorFoto, Egemen
dc.contributor.authorOzdemir, Naciye
dc.contributor.authorFoto, Fatma Zilifdar
dc.contributor.authorArslan, Gulsin
dc.contributor.authorSargin, Idris
dc.date.accessioned2024-02-23T14:03:09Z
dc.date.available2024-02-23T14:03:09Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractDue to their antibacterial activity, chitosan-carbon dot composites possess great potential for pharmaceuticals, medicine, and food preservation. Conducting a comprehensive study of the interactions between chitosan, carbon dots, and bacteria is crucial to understanding the processes behind applying these composites. This study aimed to immobilize carbon dots (C-dots) synthesized from Elaeagnus angustifolia fruits on chitosan and glass microbeads' surfaces, to characterize the test materials obtained after synthesis and immobilization, and to investigate their antibacterial potentials.C-dot synthesis was carried out from water extract in an acidic medium with the help of microwave irradiation, and their structural and optical properties were characterized by TEM, XRD, FT-IR, UV-vis, Zeta potential, and fluorescence methods. The surface of the glass microbeads was first activated and functionalized with surface amine groups with a silaning agent. C-dots were immobilized on both glass and chitosan microbeads using a crosslinking agent. Antibacterial potentials of nine different test materials, obtained before or after immobilization, were evaluated both qualitatively (MIC and MBC) and quantitatively (GI50) on E. coli, S. typhimurium, B. subtilis, and S. aureus, with the standard broth microdilution method.FT-IR and SEM-EDX analyses showed that C-dots were immobilized on chitosan (<1 mm) and glass (<100 mu m) microbead surfaces. C-dots reduced the cell viability by similar to 25 % on S. typhimurium and B. subtilis (MIC = 25 mg/ mL). It was also found that the highest antibacterial effect was recorded for C-dots-glass microbeads, which had a toxic effect of 43 % on S. aureus. In addition, binding C-dots to glass microbeads increased the antibacterial effect selectively in Gram-positive bacteria, while binding to chitosan microbeads was effective in all bacteria. The study showed that the antibacterial potential of C-dots-chitosan microbeads is more effective than C-dots-glass microbeads. C-dots could be used as carbon-based nanomaterials in antibacterial surface preparation once immobilized.en_US
dc.description.sponsorshipSelcuk University Research Foundation, Konya, Turkey [BAP-23401088]en_US
dc.description.sponsorshipThis study was funded by Selcuk University Research Foundation, Konya, Turkey (BAP-23401088) .en_US
dc.identifier.doi10.1016/j.ijbiomac.2023.128586
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid38056753en_US
dc.identifier.scopus2-s2.0-85179011383en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.128586
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11982
dc.identifier.volume257en_US
dc.identifier.wosWOS:001134571700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal Of Biological Macromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectGlassen_US
dc.subjectCarbon Dotsen_US
dc.subjectMicrobeadsen_US
dc.subjectElaeagnus Angustifoliaen_US
dc.subjectAntibacterial Activityen_US
dc.titleAntibacterial potentials of carbon dots immobilized on chitosan and glass surfacesen_US
dc.typeArticleen_US

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