Effect of injectable medroxyprogesterone acetate and etonogestrel implants on GABA-A and serotonin receptors in white and gray matter of the brain: experimental study in rats

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dc.contributor.authorSeven, Ali
dc.contributor.authorYuksel, Beril
dc.contributor.authorKilic, Sevtap
dc.contributor.authorEsen, Hasan
dc.contributor.authorKeskin, Ugur
dc.contributor.authorUlubay, Mustafa
dc.contributor.authorOzekinci, Murat
dc.date.accessioned2024-02-23T14:34:37Z
dc.date.available2024-02-23T14:34:37Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractThe aim of this study was to evaluate the time-dependent effect of progesterone-only contraceptives on the brain and to obtain an improved understanding of mood disorders experienced under this medication. A total of 66 Wistar albino rats were divided into three groups: etonogestrel (ENG) implant (group 1, n = 30); depot medroxyprogesterone acetate (MPA)-injectable (group 2, n = 30); and control (group 3, n = 6) groups. Groups 1 and 2 were each divided into five subgroups, which were examined every 10 d for up to 50 d after medication administration, to evaluate its time-dependent effect. There was no difference in terms of gamma-aminobutyric acid (GABA) and serotonin immunohistochemical staining in white and gray matter among the subgroups of group 1. In group 2, there was a significant decrease in serotonin receptor staining intensity in white and gray matter on day 50, when compared to the control group (p = 0.041). When the subgroups of group 2 were compared, there was a significant decrease in serotonin receptor staining intensity in white and gray matter on days 40 and 50 when compared to day 10. In conclusion, we showed that ENG and MPA have no effect on apoptosis and GABA-A receptors in the brain. We also showed that MPA has time-dependent effects on serotonin receptors, which may be a possible mechanism involved in mood disorders during long-term usage of injectable progesterone-only contraceptives.en_US
dc.identifier.doi10.3109/09513590.2014.880417
dc.identifier.endpage324en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue4en_US
dc.identifier.pmid24460500en_US
dc.identifier.scopus2-s2.0-84897902245en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage320en_US
dc.identifier.urihttps://doi.org/10.3109/09513590.2014.880417
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15666
dc.identifier.volume30en_US
dc.identifier.wosWOS:000334742300016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectEtonogestrelen_US
dc.subjectGaba-Aen_US
dc.subjectMedroxyprogesterone Acetate (Mpa)en_US
dc.subjectProgesteroneen_US
dc.subjectSerotoninen_US
dc.titleEffect of injectable medroxyprogesterone acetate and etonogestrel implants on GABA-A and serotonin receptors in white and gray matter of the brain: experimental study in ratsen_US
dc.typeArticleen_US

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