Does Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?

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dc.contributor.authorCaliskan, Mustafa
dc.contributor.authorCaklili, Ozge Telci
dc.contributor.authorCaliskan, Zuhal
dc.contributor.authorDuran, Cevdet
dc.contributor.authorCiftci, Faika C.
dc.contributor.authorAvci, Enver
dc.contributor.authorGullu, Hakan
dc.date.accessioned2024-02-23T14:24:08Z
dc.date.available2024-02-23T14:24:08Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackgroundGestational diabetes mellitus (GDM) is defined as glucose intolerance that has begun during pregnancy. Recent studies have proven that development of atherosclerosis may be established in this population even without presence of type 2 diabetes. For assessment of atherosclerosis, epicardial fat thickness (EFT) is recently being used as a surrogate marker. In this study, we aimed to prove that women with GDM history are more inclined to have higher EFT levels than women without GDM history. MethodsSixty-two patients with previous GDM and 33 age- and sex-matched controls were allocated. Epicardial fat thicknesses of the subjects were measured with transthorasic echocardiography and carotid intima media thickness (c-IMT) was measured with ultrasound. Insulin resistance (IR) of each subject was assessed with Homeostasis model of assessmentinsulin resistance (HOMA-IR). ResultsCarotid IMT and EFT were significantly higher in previous GDM group than controls. Serum gamma-glutamyl transferase (GGT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) levels were also found significantly higher in the patients with previous GDM as compared to the controls. We observed that carotid IMT (=310, P=0.003), total cholesterol (=315, P=0.002), BMI (=308, P=0.002), HbA1c (=227, P=0.018), and HOMA-IR (=184, P=0.049) were independently correlated with EFT. ConclusionsAlthough the number of patients included in this study is limited, high EFT results may indicate presence of atherosclerosis in women with previous GDM.en_US
dc.identifier.doi10.1111/echo.12597
dc.identifier.endpage1187en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue10en_US
dc.identifier.pmid24666015en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1182en_US
dc.identifier.urihttps://doi.org/10.1111/echo.12597
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13833
dc.identifier.volume31en_US
dc.identifier.wosWOS:000344854600011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal Of Cardiovascular Ultrasound And Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectEchocardiographyen_US
dc.subjectEpicardial Faten_US
dc.subjectGestational Diabetesen_US
dc.titleDoes Gestational Diabetes History Increase Epicardial Fat and Carotid Intima Media Thickness?en_US
dc.typeArticleen_US

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