Utility of Different Scoring Systems for the Diagnosis of Thrombotic Microangiopathies

Basit Öğe Kaydı
dc.contributor.authorYilmaz, Seda
dc.contributor.authorCenelI, Ozcan
dc.contributor.authorTekinalp, Atakan
dc.date.accessioned2024-02-23T14:34:24Z
dc.date.available2024-02-23T14:34:24Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective: To investigate the appropriateness of Bentley and plasmic scores and ADAMTS-13 activity to distinguish between primary thrombotic microangiopathies (TMA) syndromes and other thrombotic microangiopathies, as well as primary thrombotic microangiopathies (TTP, complement-related TMA, etc).Study Design: Descriptive study.Place and Duration of the Study: Department of Hematology, Faculty of Medicine, from February 2013 to February 2020.Methodology: Data of patients with non-immune hemolytic anaemia (MAHA) and thrombocytopenia who had ADAMTS-13 test, were analysed. Clinical and laboratory findings, Bentley and plasmic scores, and ADAMTS activity levels were compared.Results: The patients were grouped as primary (n = 27) and secondary (n = 28) TMA, the age was median 38.0 (18-63) years in the primary TMA group and 49.5 (20-84) years in the secondary TMA group. Neurological findings were less in the secondary TMA group (p = 0.008). Plasmic score, lactate dehydrogenase, and total and indirect bilirubin levels were high and D-dimer levels were low in the primary TMA group. In the primary TMA group, a greater number of patients with high plasmic scores were found, whereas all patients in the secondary TMA group had low risk according to Bentley score. Calcium levels were high and platelet levels were low in those with ADAMTS activity level <10% (p = 0.006). The evaluation of primary TMAs demonstrated significant differences in platelet, urea, creatinine, and sodium values between the two groups.Conclusion: Laboratory data and clinical scores are valuable in differentiating primary and other TMA.en_US
dc.identifier.doi10.29271/jcpsp.2023.05.539
dc.identifier.endpage543en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue5en_US
dc.identifier.pmid37190689en_US
dc.identifier.scopus2-s2.0-85159455191en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2023.05.539
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15592
dc.identifier.volume33en_US
dc.identifier.wosWOS:000991064000011en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBentley Scoreen_US
dc.subjectComplementen_US
dc.subjectPlasmic Scoreen_US
dc.subjectThrombotic Microangiopathyen_US
dc.subjectThrombotic Thrombocytopenic Purpuraen_US
dc.subjectAdamts-13en_US
dc.titleUtility of Different Scoring Systems for the Diagnosis of Thrombotic Microangiopathiesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu