Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group

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dc.contributor.authorYildiz, Abdulmecit
dc.contributor.authorUlu, Sena
dc.contributor.authorOruc, Aysegul
dc.contributor.authorUcar, Ali Riza
dc.contributor.authorOzturk, Savas
dc.contributor.authorAlagoz, Selma
dc.contributor.authorEren, Necmi
dc.date.accessioned2024-02-23T14:20:16Z
dc.date.available2024-02-23T14:20:16Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 +/- 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m(2) (IQR, 75.4-116.3), and median proteinuria was 6000 mg/d (IQR, 3656-9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.en_US
dc.identifier.doi10.1080/0886022X.2022.2079526
dc.identifier.endpage1059en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue1en_US
dc.identifier.pmid35786180en_US
dc.identifier.scopus2-s2.0-85133243986en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1048en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2022.2079526
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13096
dc.identifier.volume44en_US
dc.identifier.wosWOS:000820567200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHistopathologyen_US
dc.subjectImmunofluorescenceen_US
dc.subjectPrimary Membranous Nephropathyen_US
dc.subjectNephrotic Syndromeen_US
dc.subjectTurkeyen_US
dc.subjectKidney Biopsyen_US
dc.titleClinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Groupen_US
dc.typeArticleen_US

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