Neutrophil-lymphocyte and Platelet-lymphocyte Ratios among Adolescents with Substance Use Disorder: A Preliminary Study

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dc.contributor.authorKaratoprak, Serdar
dc.contributor.authorUzun, Necati
dc.contributor.authorAkinci, Mehmet Akif
dc.contributor.authorDonmez, Yunus Emre
dc.date.accessioned2024-02-23T14:44:57Z
dc.date.available2024-02-23T14:44:57Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: Substance use disorder (SUD) is a serious public health problem affecting both the individual and the society, and substance use-related deaths and disability have been shown to increase gradually. Recent etiologic studies have reported that there is a relation between inflammatory parameters and psychiatric disorders. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) used as an indicator of inflammation have been shown to be increased in various psychiatric disorders. In this study, we aimed to investigate the NLR and PLR in adolescents with SUD. Methods: This study was conducted by retrospectively examining the records of 55 male adolescents who were followed up with SUD in a child and adolescent psychiatry outpatient clinic between November 2019-June 2020. Patients who had comorbid psychiatric disorder were included, and those who received any psychotropic medication were excluded. A total of 61 healthy male adolescents in the same age range without any psychiatric disorders were recruited as a control group. Neutrophil-lymphocyte-platelet counts were noted retrospectively from complete blood tests, and NLR-PLR were calculated. Results: The NLR and PLR of adolescents with SUD were significantly higher than the healthy adolescents (p < 0.01, p < 0.01, respectively). In addition, conduct disorder, depression, and attention deficit/hyperactivity disorder, which were determined as the most common comorbid psychiatric disorders had no effects on NLR (p = 0.513, p = 0.584, p = 0.394, respectively) and PLR (p = 0.210, p = 0.346, p = 0.359, respectively). Conclusion: The results of current study indicate that inflammatory processes may have a key role in the pathophysiology of SUD.en_US
dc.identifier.doi10.9758/cpn.2021.19.4.669
dc.identifier.endpage676en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue4en_US
dc.identifier.pmid34690121en_US
dc.identifier.scopus2-s2.0-85119678368en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage669en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.2021.19.4.669
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17168
dc.identifier.volume19en_US
dc.identifier.wosWOS:000712048500009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology And Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubstance Use Disorderen_US
dc.subjectInflammationen_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyteen_US
dc.subjectPlateleten_US
dc.subjectAdolescentsen_US
dc.titleNeutrophil-lymphocyte and Platelet-lymphocyte Ratios among Adolescents with Substance Use Disorder: A Preliminary Studyen_US
dc.typeArticleen_US

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