Investigation of CCL1 rs159294 T/A gene polymorphism in pulmonary and extrapulmonary tuberculosis patients

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dc.contributor.authorOzdemir, Fethi Ahmet
dc.contributor.authorErol, Deniz
dc.contributor.authorYuce, Hueyin
dc.contributor.authorKonar, Vahit
dc.contributor.authorSenli, Ebru Kara
dc.contributor.authorBulut, Funda
dc.contributor.authorDeveci, Figen
dc.date.accessioned2024-02-23T14:41:48Z
dc.date.available2024-02-23T14:41:48Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractIntroduction: The purpose of this study is to reveal whether CCL1 rs159294 T/A polymorphism in pulmonary and extrapulmonary tuberculosis patients pose a risk to catch tuberculosis or not. Materials and Methods: In the study, peripheral blood samples from the control group, which includes 160 patients, who consulted to Firat University Faculty of Medicine, Pulmonology Policlinic in Elazig province and who were diagnosed with tuberculosis; and 160 healthy individuals, were taken and put into tubes containing EDTA. Each tube contained 2 cc blood samples. DNA isolation was made from these blood samples and CCL1 rs159294 T/A polymorphism was defined with PCR-RFLP analysis. Results: For CCL1 rs159294 T/A polymorphism, TT genotype was found in 98 (61.3%) patients, TA genotype was found in 58 (36.3%) patients, AA genotype was found in 4 (2.5%) patients among 160 patients with tuberculosis; and TT genotype was found in 50 (70.4%) patients, TA genotype in 20 (28.2%) patients, AA genotype was found in 1 (1.4%) patient among 71 patients with pulmonary tuberculosis; TT genotype was found in 48 (53.9%) patients TA genotype was found in 38 (42.7%) patients and AA genotype was found in 3 (3.4%) patients among 89 extrapulmonary tuberculosis patients. And in control group, among 160 healthy individuals, TT genotype was found in 100 (62.5%) individuals, TA genotype was found in 58 (36.3%) individuals, AA genotype was found in 2 (1.3%) individuals and no statistically significant difference was found. Conclusion: CCL1 rs159294 T/A polymorphism do not form an inclination to tuberculosis in our population.en_US
dc.identifier.doi10.5578/tt.5481
dc.identifier.endpage208en_US
dc.identifier.issn0494-1373
dc.identifier.issue3en_US
dc.identifier.pmid24298961en_US
dc.identifier.scopus2-s2.0-84888774242en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://doi.org/10.5578/tt.5481
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17013
dc.identifier.volume61en_US
dc.identifier.wosWOS:000421333900004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Assoc Tuberculosis & Thoraxen_US
dc.relation.ispartofTuberkuloz Ve Torak-Tuberculosis And Thoraxen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary Tuberculosisen_US
dc.subjectExtrapulmonary Tuberculosisen_US
dc.subjectCcl1en_US
dc.subjectPolymorphismen_US
dc.titleInvestigation of CCL1 rs159294 T/A gene polymorphism in pulmonary and extrapulmonary tuberculosis patientsen_US
dc.typeArticleen_US

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