The role of heparin-binding protein in the diagnosis of acute mesenteric ischemia

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dc.contributor.authorKocak, Sedat
dc.contributor.authorAcar, Tarik
dc.contributor.authorErtekin, Birsen
dc.contributor.authorGuven, Merve
dc.contributor.authorDundar, Zerrin Defne
dc.date.accessioned2024-02-23T14:41:39Z
dc.date.available2024-02-23T14:41:39Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Acute mesenteric ischemia (AMI) is associated with a high mortality rate, yet diagnostic difficulties persist. Although many biomarkers have been investigated for diagnostic purposes, as well as imaging methods, a sufficiently specific and sensitive marker has not been identified. This research was designed to examine whether heparin-binding protein (HBP), which has a role in the early phase of inflammation, could be useful in the diagnosis of AMI. METHODS: Serum samples obtained from a previously performed rabbit model of AMI were used in the study. HBP, C-reactive protein (CRP) and interleukin 6 (IL-6) levels were measured in blood samples obtained at baseline and 1, 3, and 6 hours from subjects that were separated into 3 groups: control, sham, and ischemia. The change in each marker over time and comparisons of the groups were evaluated statistically. RESULTS: A significant difference was not detected at the first hour in any of the studied markers. At the third hour, the CRP and IL-6 levels in the ischemia group indicated a significant increase in comparison with the control and sham groups (p<0.001). The HBP values showed a significant increase at the sixth hour in the ischemia group in comparison with the others (p<0.001). CONCLUSION: The HBP level demonstrated a slower increase in a rabbit model of AMI compared with CRP and IL-6. However, it still has the potential to become an early diagnostic biomarker. Diagnostic sensitivity and specificity should be evaluated in further clinical trials.en_US
dc.identifier.doi10.5505/tjtes.2018.49139
dc.identifier.endpage212en_US
dc.identifier.issn1306-696X
dc.identifier.issue3en_US
dc.identifier.pmid31135943en_US
dc.identifier.scopus2-s2.0-85066942610en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.5505/tjtes.2018.49139
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16946
dc.identifier.volume25en_US
dc.identifier.wosWOS:000469248600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Mesenteric Ischemiaen_US
dc.subjectBiomarkeren_US
dc.subjectHeparin-Binding Proteinen_US
dc.titleThe role of heparin-binding protein in the diagnosis of acute mesenteric ischemiaen_US
dc.typeArticleen_US

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