In vivo corneal confocal microscopic analysis in patients with keratoconus

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorBozkurt, Banu
dc.contributor.authorMalik, Rayaz A.
dc.date.accessioned2024-02-23T14:37:37Z
dc.date.available2024-02-23T14:37:37Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractAIM: To quantify corneal ultrastructure using laser scanning in vivo confocal microscopy (IVCM) in patients with keratoconus and control subjects. METHODS: Unscarred corneas of 78 keratoconic subjects without a history of contact lens use and 36 age-matched control subjects were evaluated with slit-lamp examination (SLE), corneal topography and laser scanning IVCM. One eye was randomly chosen for analysis. Anterior and posterior stromal keratocyte, endothelial cell and basal epithelial cell densities and sub-basal nerve structure were evaluated. RESULTS: IVCM qualitatively demonstrated enlarged basal epithelial cells, structural changes in sub -basal and stromal nerve fibers, abnormal stromal keratocytes and keratocyte nuclei, and pleomorphism and enlargement of endothelial cells. Compared with control subjects, significant reductions in basal epithelial cell density (5817 +/- 306 cells/mm(2) vs 4802 +/- 508 cells/mm(2), P<0.001), anterior stromal keratocyte density (800 +/- 111 cells/mm(2) vs 555 +/- 115 cells/mm(2), P<0.001), posterior stromal keratocyte density (333 +/- 34 cells/mm(2) vs 270 +/- 47 cells/mm(2), P<0.001), endothelial cell density (2875 +/- 223 cells/mm(2) vs 2686 +/- 265 cells/mm(2), P<0.001), sub-basal nerve fiber density (31.2 +/- 8.4 nerves/mm(2) vs 18.1 +/- 19.2 nerves/mm(2), P<0.001), sub -basal nerve fiber length (21.4 +/- 3.4 mm/mm(2) vs16.1 +/- 5.1 mm/mm(2), P<0.001), and sub-basal nerve branch density (median 50.0 (first quartile 31.2 - third quartile 68.7) nerve branches/mm(2) vs median 25.0 (first quartile 6.2 - third quartile 45.3) nerve branches/mm(2), P<0.001) were observed in patients with keratocon us. CONCLUSION: Significant microstructural abnormalities were identified in all corneal layers in the eyes of subjects with keratoconus using IVCM. This non invasive in vivo technique provides an important means to define and follow progress of microstructural changes in patients with keratoconus.en_US
dc.identifier.doi10.3980/j.issn.2222-3959.2015.03.17
dc.identifier.endpage539en_US
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue3en_US
dc.identifier.pmid26086003en_US
dc.identifier.scopus2-s2.0-84938892956en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage534en_US
dc.identifier.urihttps://doi.org/10.3980/j.issn.2222-3959.2015.03.17
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16152
dc.identifier.volume8en_US
dc.identifier.wosWOS:000355781100017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIjo Pressen_US
dc.relation.ispartofInternational Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeratoconusen_US
dc.subjectIn Vivo Confocal Microscopyen_US
dc.subjectCorneal Nervesen_US
dc.titleIn vivo corneal confocal microscopic analysis in patients with keratoconusen_US
dc.typeArticleen_US

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