Abdominal Ischemia-Reperfusion Induced Cardiac Dysfunction Can Be Prevented by MitoTEMPO

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dc.contributor.authorAkkoca, Ahmet
dc.contributor.authorCelen, Murat Cenk
dc.contributor.authorTuncer, Seckin
dc.contributor.authorDalkilic, Nizamettin
dc.date.accessioned2024-02-23T14:20:17Z
dc.date.available2024-02-23T14:20:17Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground Cardiac dysfunction is secondary to acute mesenteric ischemia (AMI) and abdominal aortic aneurysms (AAA). The underlying cause of distant organ damage in the heart is the formation of oxidative stress caused by ischemia-reperfusion. In this study, we investigated the possible protective effects of a novel mitochondria-targeted antioxidant MitoTEMPO on contractile dysfunction and structural defects of the rat papillary muscle caused by abdominal ischemia-reperfusion (AIR). Methods and Results In the experiments, adult Wistar-Albino rats were used and animals were divided randomly into 3 groups; sham-operated group (SHAM), an IR group that had aortic cross-clamping for 1 h followed by 2 h reperfusion, and a third group that received protective 0.7 mg/kg/day MitoTEMPO injection for 28-day before IR. As a result, it was observed that MitoTEMPO injection had a protective effect on the mechanical activities and structural properties of the papillary muscle impaired by AIR. Our study also showed that AIR disrupted the contractile function of the papillary muscle for each stimulation frequency and post-potentiation responses tested. This is common for each measured and calculated mechanical parameter and MitoTEMPO injection showed its protective effects. Conclusion Consequently, calcium homeostasis seems to be impaired by AIR, and MitoTEMPO may exert its protective effect through energy metabolism by directly targeting the mitochondria.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Necmettin Erbakan University, Meram, Konya, Turkey [171318004]; Akkoca A.'s master of science thesisen_US
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Coordinatorship of Necmettin Erbakan University (Fund No: 171318004), Meram, Konya, Turkey, and Akkoca A.'s master of science thesis.en_US
dc.identifier.doi10.1080/08941939.2021.1902593
dc.identifier.endpage583en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue3en_US
dc.identifier.pmid33761811en_US
dc.identifier.scopus2-s2.0-85103208635en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage577en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2021.1902593
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13101
dc.identifier.volume35en_US
dc.identifier.wosWOS:000632724200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMitotempoen_US
dc.subjectPapillary Muscleen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectMuscle Contractionen_US
dc.titleAbdominal Ischemia-Reperfusion Induced Cardiac Dysfunction Can Be Prevented by MitoTEMPOen_US
dc.typeArticleen_US

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