Impact of Continuous Positive Airway Pressure Treatment on Leptin Levels in Patients with Obstructive Sleep Apnea Syndrome

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dc.contributor.authorYosunkaya, Sebnem
dc.contributor.authorOkur, Hacer Kuzu
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorZamani, Adil
dc.contributor.authorKutlu, Ruhusen
dc.date.accessioned2024-02-23T14:20:58Z
dc.date.available2024-02-23T14:20:58Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: There is growing evidence that leptin regulation is altered in obstructive sleep apnea syndrome (OSAS). Several potential mechanisms have been purported to explain how sleep apnea may alter leptin levels. We investigated whether repeated apneas, hypoxia, or excessive daytime sleepiness influenced the levels of leptin in OSAS patients. We also evaluated whether a 3-month continuous positive airway pressure (CPAP) treatment affected leptin levels in patients. Methods: Randomly selected 31 untreated, otherwise healthy male, overweight [body mass index (BMI) >25kg/m(2)] obstructive sleep apnea syndrome (OSAS) patients [apnea-hypopnea index (AHI) 15] and 25 control (AHI <5) were included in this study. To confirm the diagnosis, all subjects underwent standard polysomnography. Serum samples were taken at 07:00-08:00 a.m. after overnight fasting. The OSAS patients that had regular CPAP treatment (n=26) were re-evaulated 3 months later. Results: Leptin levels (50.517.5 grams/L in OSAS and 56.3 +/- 25.5 grams/L in controls) and lipid profiles (TC, TGs, HDL-C, and LDL-C) between patient and control groups did not differ (P>0.05). Leptin levels were not correlated with the AHI, oxygen saturation, or excessive daytime sleepiness. CPAP treatment did not significantly change the (BMI), waist and neck circumference, or leptin levels in OSAS patients. Furthermore, we found no correlation between the decrease in serum leptin levels and parameters that were improved by CPAP treatment. Conclusion: Leptin levels and lipid profile of overweight subjects with and without OSAS were not different, and our results suggest that OSAS-related parameters and CPAP treatment do not play a significant role in the serum leptin levels.en_US
dc.identifier.doi10.1089/met.2014.0161
dc.identifier.endpage277en_US
dc.identifier.issn1540-4196
dc.identifier.issn1557-8518
dc.identifier.issue6en_US
dc.identifier.pmid25867002en_US
dc.identifier.scopus2-s2.0-84937545870en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage272en_US
dc.identifier.urihttps://doi.org/10.1089/met.2014.0161
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13384
dc.identifier.volume13en_US
dc.identifier.wosWOS:000363966200006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofMetabolic Syndrome And Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleImpact of Continuous Positive Airway Pressure Treatment on Leptin Levels in Patients with Obstructive Sleep Apnea Syndromeen_US
dc.typeArticleen_US

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