NORMOCORTISOLEMIA AFTER TEN DAYS OCTREOTIDE TREATMENT IN A PATIENT WITH ECTOPIC CUSHING'S SYNDROME DUE TO BRONCHIAL CARCINOID

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dc.contributor.authorKaya, A.
dc.contributor.authorCakir, M.
dc.contributor.authorTuran, E.
dc.contributor.authorKulaksizoglu, M.
dc.contributor.authorTastekin, G.
dc.contributor.authorAltinok, T.
dc.date.accessioned2024-02-23T14:38:01Z
dc.date.available2024-02-23T14:38:01Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractContex. We report the use of subcutaneous somatostatin injection three times a day to decrease hypercortisolism in a patient who had Cushing's syndrome induced by bronchial carcinoid tumour progressive pneumonia due to immune suppression. Subject and Method. A 46-year-old man with 7-month history of DM type-2, hypertension and cerebrovascular-disease, vertebral compression-fracture was admitted to our clinic. Physical examination was consistent with Cushing's syndrome. Laboratory results revealed hyperglycemia (143 mg/dL; reference range, <100 mg/dL) and hypokalemia (2.29 mEq/L; reference range, 3.5-5.1 mEq/L). His morning serum cortisol was 40 mu g/dL (reference range 6.7-22.6 mu g/dL), urine cortisol-excretion was 2245 mu g/24 hours (reference range 58-403 mu g/24 hours), after 1 mg dexamethasone-suppression test serum cortisol was 28 mu g/dL (6.7-22.6 mu g/dL) and ACTH 354 pg/mL (reference range 7.9-66 pg/mL). Adrenal CT and hypophyseal MRI were normal. An ectopic source was searched for Cushing's syndrome. Chest CT scan of the right lung showed 12x9 mm nodule. High fever cough occurred on the follow-up. Chest radiograph revealed diffuse pneumonic infiltration. Despite 3-drug antibiotic combination therapy, infection did not improve. Subcutaneous injection of octreotide 3x100 mu g was initiated to decrease hypercortisolism. The infection improved rapidly after the therapy. The morning serum cortisol, urine cortisol-excretion, ACTH was at the upper normal range (77.1 pg/mL, reference range 7.9-66 pg/mL) on 10th day of treatment. The patient was a consulted for surgery and the nodule was excised. The pathology was consistent carcinoid tumor. Conclusion. Subcutaneous octreotide treatment may be helpful to gain time for exploring the focus in ectopic cushing's syndrome and to control the serious infections due to hypercortisolism.en_US
dc.identifier.doi10.4183/aeb.2013.467
dc.identifier.endpage472en_US
dc.identifier.issn1841-0987
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84883138256en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2013.467
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16332
dc.identifier.volume9en_US
dc.identifier.wosWOS:000324225700014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharesten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEctopic Cushing's Syndromeen_US
dc.subjectOctreotideen_US
dc.subjectCarcinoid Tumoren_US
dc.titleNORMOCORTISOLEMIA AFTER TEN DAYS OCTREOTIDE TREATMENT IN A PATIENT WITH ECTOPIC CUSHING'S SYNDROME DUE TO BRONCHIAL CARCINOIDen_US
dc.typeArticleen_US

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