The Antiepileptic and Antidepressant-Like Effects Of Dexpanthenol in Female Swiss Albino Mice

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dc.contributor.authorInan, Salim Yalcin
dc.contributor.authorAcikgoz, Yagmur
dc.date.accessioned2024-02-23T14:34:54Z
dc.date.available2024-02-23T14:34:54Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: Oxidative stress is one of the main mechanisms of epilepsy and depression. Based on our information, behavioral effects of dexpanthenol in animals have not yet been demonstrated. Dexpanthenol itself is a topical medicine to restore skin barrier against infections caused by microorganisms which also stimulates the peristaltic movements in the gut when administered parenterally; however since it is cheap and easy to use with minor side effects, the main idea of the current research was to evaluate whether dexpanthenol has an antiepileptic and/or antidepressant-like effects. Methods: A group of female Swiss albino mice (25-30 g) were injected with dexpanthenol (ip, N = 8) or saline (ip, N = 8), and 30 min later pentylenetetrazole (65 mg/kg, ip)-induced convulsions were determined for 30 min. In addition, another group of mice were again injected with dexpanthenol (500 mg/kg, ip, N = 8) or saline (ip, N = 8) and immobility time were evaluated in the forced swim test. Finally, mouse righting reflex test was used to assess the possible changes in motor coordination. Results: Our data showed that dexpanthenol, at the dose of 500 mg/kg displayed significant antiepileptic and antidepressant-like effects without affecting motor behavior. Conclusions: A common low-cost topical drug for various skin disorders that can also be given parenterally for motility regulation has an antiepileptic and antidepressant-like activity in mice.en_US
dc.identifier.doi10.33808/clinexphealthsci.865421
dc.identifier.endpage144en_US
dc.identifier.issn2459-1459
dc.identifier.issue1en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.865421
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15808
dc.identifier.volume12en_US
dc.identifier.wosWOS:000782846300021en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpilepsyen_US
dc.subjectDepressionen_US
dc.subjectDexpanthenolen_US
dc.subjectMiceen_US
dc.titleThe Antiepileptic and Antidepressant-Like Effects Of Dexpanthenol in Female Swiss Albino Miceen_US
dc.typeArticleen_US

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