Association between endocrinological, immunological and psychosocial variables in psoriasis patients

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dc.contributor.authorBilgic, Ozlem
dc.contributor.authorBilgic, Ayhan
dc.contributor.authorSivrikaya, Abdullah
dc.contributor.authorSelvi, Yavuz
dc.contributor.authorUnlu, Ali
dc.contributor.authorAltinyazar, Hilmi C.
dc.date.accessioned2024-02-23T14:48:53Z
dc.date.available2024-02-23T14:48:53Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Selcuk University [14401048]en_US
dc.description.sponsorshipFunding Funding for this study was provided by a grant from the Scientific Research Project Coordination Unit of Selcuk University (Project no: 14401048).en_US
dc.identifier.endpage609en_US
dc.identifier.issn0392-0488
dc.identifier.issn1827-1820
dc.identifier.issue6en_US
dc.identifier.pmid27824222en_US
dc.identifier.scopus2-s2.0-84994716172en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17869
dc.identifier.volume151en_US
dc.identifier.wosWOS:000393354300003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofGiornale Italiano Di Dermatologia E Venereologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLife Change Eventsen_US
dc.subjectAdult Survivors Of Child Adverse Eventsen_US
dc.titleAssociation between endocrinological, immunological and psychosocial variables in psoriasis patientsen_US
dc.typeArticleen_US

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