Effects of SGLT2 Inhibitors as an Add-on Therapy to Metformin on Electrocardiographic Indices of Ventricular Repolarization
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taiwan Soc Cardiology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: According to EMPA-REG OUTCOME, trial use of empagliflozin in patients with a history of cardiovascular disease improves hospitalization for heart failure and decreases cardiovascular morbidity and mortality. Recent studies have shown that a prolonged T-peak to T-end interval on the resting electrocardiography is associated with an increased risk of cardiovascular mortality. Tp-e/corrected QT interval (QTc) ratio is a reliable index of prolonged ventricular repolarization. Objectives: In this study, we examined the effects of sodium glucose co-transporters 2 (SGLT2) inhibitors as an add-on therapy to metformin on electrocardiographic indices of ventricular repolarization. Methods: Electrocardiographic recordings before combination therapy along with three months and six months follow-up of 141 consecutive patients who were switched from monotherapy to combination therapy with two oral agents due to inadequate glycemic control were derived. QT interval (QT), QTc, Tp-e intervals and Tp-e/QT, Tp-e/QTc ratios were calculated and analyzed. Results: After the six month follow-up, there was a significant decrease in the QT interval in patients who were using SGLT2 inhibitors as an add-on therapy to metformin compared to other glucose-lowering agents (373.4 +/- 9.9 ms vs. 385.4 +/- 12.5 ms, 382.9 +/- 11.2 ms; p < 0.001 respectively). Furthermore, Tp-e/QT and Tp-e/QTc ratios were significantly lower in this patient population compared to control groups (0.186 +/- 0.023 vs. 0.196 +/- 0.021, 0.191 +/- 0.017; p < 0.001 and 0.174 +/- 0.021 vs. 0.199 +/- 0.022, 0.195 +/- 0.016; p < 0.001 respectively). Conclusion: Our data showed that using SGLT2 inhibitors as an add-on therapy to metformin favorably alters ventricular repolarization indices in patients with type 2 diabetes mellitus.
Açıklama
Anahtar Kelimeler
Diabetes Mellitus, Repolarization, 12-Lead Electrocardiogram
Kaynak
Acta Cardiologica Sinica
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
36
Sayı
6
