Predicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IR

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dc.contributor.authorAlptekin, Husnu
dc.contributor.authorCizmecioglu, Ahmet
dc.contributor.authorIsik, Hatice
dc.contributor.authorCengiz, Turkan
dc.contributor.authorYildiz, Murat
dc.contributor.authorIyisoy, Mehmet Sinan
dc.date.accessioned2024-02-23T14:00:10Z
dc.date.available2024-02-23T14:00:10Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractPurpose To determine the predictability of gestational diabetes mellitus (GDM) during the first trimester using the degree of insulin resistance and anthropometric measurements and to assign the risk of developing GDM by weight gained during pregnancy (WGDP). Methods A total of 250 singleton pregnancies at 7-12 gestational weeks were studied. Body mass index (BMI), waist/hip ratio (WHR), quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR) scores and WGDP were determined. The backward stepwise method was applied to estimate possible associations with GDM. Cutoff points were estimated using receiver operating characteristic curve analysis. Results GDM was found in 20 of 227 singleton pregnancies (8.8 %). The calculated HOMA-IR, QUICKI, BMI, WHR, WGDP, and parity were significantly associated with GDM. Logistic regression analyses showed that three covariates (HOMA-IR, BMI, WGDP) remained independently associated with GDM. It was calculated as OR 1.254 (95 % CI 1.006-1.563), AUC 0.809, sensitivity 90 %, specificity 61 % with cutoff = 2.08 for HOMA-IR; OR 1.157 (CI 1.045-1.281), AUC 0.723, sensitivity 80 %, specificity 58 % with cutoff = 25.95 for BMI; OR 1.221, (CI 1.085-1.374), AUC 0.654, sensitivity 80 %, specificity 46 % with cutoff = 4.7 for WGDP. Despite a HOMA-IR score of > 3.1 in pregnant women, GDM was detected in only three of 29 patients (10.3 %) if WGDP was < 4.7 kg at weeks 24-28. Conclusions First trimester screening for GDM can be achieved based on maternal anthropometric measurements and HOMA-IR. In particular, if BMI is > 25.95 kg/m(2) and the HOMA-IR score > 2.08, controlling weight gain may protect against GDM.en_US
dc.identifier.doi10.1007/s40618-015-0427-z
dc.identifier.endpage583en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue5en_US
dc.identifier.pmid26754418en_US
dc.identifier.scopus2-s2.0-84964370079en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage577en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-015-0427-z
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11486
dc.identifier.volume39en_US
dc.identifier.wosWOS:000374102700012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFirst Trimester Pregnancyen_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectInsulin Resistanceen_US
dc.subjectBody Mass Indexen_US
dc.subjectWaist/Hip Ratioen_US
dc.subjectWeight Gainen_US
dc.titlePredicting gestational diabetes mellitus during the first trimester using anthropometric measurements and HOMA-IRen_US
dc.typeArticleen_US

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