Effectiveness of collagenase in preventing postoperative intra-abdominal adhesions

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dc.contributor.authorCakir, Murat
dc.contributor.authorTekin, Ahmet
dc.contributor.authorKucukkartallar, Tevfik
dc.contributor.authorYilmaz, Huseyin
dc.contributor.authorBelviranli, Metin
dc.contributor.authorKartal, Adil
dc.date.accessioned2024-02-23T14:03:14Z
dc.date.available2024-02-23T14:03:14Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractIntroduction: The purpose of this study is to investigate the effectiveness of Collagenase clastridiopeptidase an enzyme preparation used in enzymatic debridement in preventing adhesions brought about by peritoneal damage. Methods: The study covers a total of 40 rats in 4 groups each having 10 rats. Group 1: The control group. Group 2: Normal saline group. Group 3: Sterile Novuxol (R) group. Group 4: The group where the intraperitoneal and systemic effects of sterile Novuxol (R) were investigated. Adhesion frequency and grades were scored on the post-op 11th day according to Granat. Blood work including hemoglobin, aspartate aminotransferase, alanine aminotransferase, urea, creatinine, and albumin level measurements were performed. Toxicity was investigated histopathologically through samples taken from the liver and the peritoneum from Group 4. Results: Adhesion frequency was found to be 80% on the right and 90% on the left for Group 1, while it was 50% on both left and right for Group 2, and 30% on the right and 10% on the left for Group 3. Adhesion stages were found to be 1: 2.35 +/- 1.42 for Group 1, 0.31 +/- 1.15 for Group 2, and 0.20 +/- 0.41 for Group 3. Adhesion stage of the Sterile Novuxol (R) Group was lower than all the other groups (p < 0.05). Biochemical and hematological parameters were similar in all groups (p > 0.05). Histopathological analysis revealed no hepatotoxicity. Conclusions: According to the results of our study, we believe that Sterile Novuxol (R) can be a good anti-adhesive agent considering its ease of use, non-toxicity, and effectiveness. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijsu.2013.04.001
dc.identifier.endpage491en_US
dc.identifier.issn1743-9191
dc.identifier.issue6en_US
dc.identifier.pmid23587652en_US
dc.identifier.scopus2-s2.0-84878899770en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage487en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2013.04.001
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12033
dc.identifier.volume11en_US
dc.identifier.wosWOS:000320541500011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntra-Abdominalen_US
dc.subjectAdhesionsen_US
dc.subjectCollagenaseen_US
dc.subjectPostoperativeen_US
dc.titleEffectiveness of collagenase in preventing postoperative intra-abdominal adhesionsen_US
dc.typeArticleen_US

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