Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.
Açıklama
Anahtar Kelimeler
Ischemia-Modified Albumin, Oxidative Stress, Postherpetic Neuralgia, Thiol/Disulfide
Kaynak
Journal Of Laboratory Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
43
Sayı
5
