The effect of epidermal growth factor applied locally for pelviureteral anastomoses

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dc.contributor.authorYurtcu, Muslim
dc.contributor.authorBaba, Zeliha Fusun
dc.date.accessioned2024-02-23T14:45:48Z
dc.date.available2024-02-23T14:45:48Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: To investigate the effect of epidermal growth factor (EGF) on fibrous tissue formation and wound healing in experimental pelviureteral anastomosis (PUA). Materials and Methods: Twelve rabbits were divided equally into 2 groups: control (C) and epidermal growth factor (EGF). A 1-cm length of the ureteropelvic segment was resected through a laparotomy incision and then anastomosis was performed. The rabbits were administered locally with 100 mu g/kg EGF (EGF group) all around the anastomosis lines after the surgical procedure. The C group did not receive any medication during their procedure. Intravenous pyelography was carried out on postoperative day 21. The rabbits were sacrificed and dissected under a dissecting microscope and examined for acute inflammation (AI), chronic inflammation (CI), granulation tissue amount (GTA), granulation tissue fibroblast maturation (GTFM), collagen deposition (CD), neovascularization (N), re-epithelization (R), and peripheral tissue reaction (PTR) in the anastomosis lines 3 weeks later. Results: There were no significant differences in the GTA, N, or R scores in the C group compared with those in the EGF group. In the EGF group, AI and CI scores were lower than they were in the C group. CD, GTFM, and PTR in the EGF group were higher than they were in the C group. Conclusion: EGF did not decrease CD, GTFM, or PTR, but did decrease important parameters in wound healing such as acute inflammation and chronic inflammation in an experimental model of PUA in rabbits.en_US
dc.identifier.endpage4231en_US
dc.identifier.issn1940-5901
dc.identifier.issue11en_US
dc.identifier.pmid25550935en_US
dc.identifier.scopus2-s2.0-85016369822en_US
dc.identifier.startpage4226en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17635
dc.identifier.volume7en_US
dc.identifier.wosWOS:000348302100046en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectPelviureteral Anastomosesen_US
dc.subjectAcute Inflammationen_US
dc.subjectChronic Inflammationen_US
dc.titleThe effect of epidermal growth factor applied locally for pelviureteral anastomosesen_US
dc.typeArticleen_US

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