Thymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in rat

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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorToker, Aysun
dc.contributor.authorPehlivan, Sultan
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorIskit, Alper Bektas
dc.date.accessioned2024-02-23T14:13:24Z
dc.date.available2024-02-23T14:13:24Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: Thymoquinone (TQ) is a potent cytoprotective, antioxidant and anti-inflammatory agent. We aimed to investigate the possible protective effects of TQ on survival, mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries in a murine sepsis model induced by cecal ligation and puncture (CLP).Methods: Wistar rats were divided into the following four groups: Sham, CLP, Sham + TQand CLP + TQ. TQ (1 mg/kg/day) or vehicle (dimethyl sulfoxide, 1 mL/kg/day) was intraperitoneally injected for 3 days. At 4th day Sham or CLP operation was applied. 20 h after the operations, MABF and contractile responses of isolated aortic rings to phenylephrine were measured. Tissue samples were obtained for histopathological and biochemical examinations. Also, survival rates were recorded throughout 96 h.Results: TQ ameliorated mesenteric hypoperfusion and partially attenuated aortic dysfunction induced by CLP. Survival rate was %0 at 42nd h in CLP group, but in CLP + TQ group it was 33.4% at the end of 96 h. Serum levels of AST, ALT, LDH, BUN, Cr and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) increased in CLP group that were prevented by TQ. The decreases in liver, spleen and kidney glutathione levels and the increases in liver, lung, kidney and spleen malondialdehyde levels induced by CLP were inhibited by TQ. The histopathological protective effects of TQ on multiple organ damage due to CLP were also observed.Conclusion: TQ has ameliorative effects on sepsis due to its protective effects on mesenteric perfusion, contractile function of aorta and its anti-inflammatory and antioxidative effects. (C) 2017 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Sp. z o.o. All rights reserved.en_US
dc.description.sponsorshipTurkish Academy of Sciences [EA-TUBA-GEBIP/2001-2-11]; Selcuk University Scientific Research Coordination [15401078]en_US
dc.description.sponsorshipAlper B. Iskit has been supported by the Turkish Academy of Sciences, in the framework of the Young Scientist Award Program (EA-TUBA-GEBIP/2001-2-11). This study was supported by Selcuk University Scientific Research Coordination (No: 15401078).en_US
dc.identifier.doi10.1016/j.pharep.2017.02.021
dc.identifier.endpage690en_US
dc.identifier.issn1734-1140
dc.identifier.issue4en_US
dc.identifier.pmid28549307en_US
dc.identifier.scopus2-s2.0-85019929237en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage683en_US
dc.identifier.urihttps://doi.org/10.1016/j.pharep.2017.02.021
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12425
dc.identifier.volume69en_US
dc.identifier.wosWOS:000413661000013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPolish Acad Sciences Inst Pharmacologyen_US
dc.relation.ispartofPharmacological Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectSepsisen_US
dc.subjectSurvivalen_US
dc.subjectMultiple Organ Damageen_US
dc.subjectVascular Hyporeactivity And Mesentericen_US
dc.subjectArterial Blood Flowen_US
dc.titleThymoquinone protects against the sepsis induced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ damage in raten_US
dc.typeArticleen_US

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