Hidden danger of COVID-19 outbreak: evaluation of subclinical myocardial dysfunction in patients with mild symptoms

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dc.contributor.authorGul, Murat
dc.contributor.authorInci, Sinan
dc.contributor.authorAktas, Halil
dc.contributor.authorYildirim, Oguz
dc.contributor.authorAlsancak, Yakup
dc.date.accessioned2024-02-23T13:56:02Z
dc.date.available2024-02-23T13:56:02Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractThe COVID-19 infection, which is caused by the novel coronavirus SARS-CoV-2, has rapidly emerged as a global public health issue. Cardiac complications secondary to this infection are common and associated with mortality. This study aimed to evaluate whether subclinical myocardial dysfunction exists in non-hospitalized mildly symptomatic COVID-19 patients using left ventricular global longitudinal strain (LVGLS). In this cross-sectional, single-center study, data were collected from non-hospitalized mildly symptomatic COVID-19 patients between January 01 and February 01, 2021. Fifty (26 male, 24 female) COVID-19 patients and 50 age- and sex-matched healthy volunteers were included in the study. Apical four-, three-, and two-chamber images were analyzed longitudinally by conventional methods and speckle tracking echocardiography (STE) for left ventricle functions. The mean age of the COVID-19 patients was 39.5 +/- 8.96, and 52% of them were male. The most prevalent presenting symptoms were fever [in 34 (68%)], asthenia [in 30 (60%)], loss of appetite [in 21 (42%)], myalgia [in 20 (40%)], and cough [in 13 (26%)]. Plasma levels of C-reactive protein (CRP) were significantly higher in the COVID-19 patients than in the controls (10.84 +/- 12.44 vs. 4.50 +/- 2.81, p < 0.001). There was no significant difference between the groups in terms of standard echocardiography and Doppler parameters (p > 0.05). Left ventricular longitudinal strain and strain velocity parameters were significantly decreased in COVID-19 patients compared to healthy individuals. LV-GLS values (- 21.72 +/- 3.85% vs. - 23.11 +/- 4.16%; p = 0.003) were significantly lower in COVID-19 patients compared with the healthy controls. Mildly symptomatic COVID-19 patients also have subclinical myocardial dysfunction similar to hospitalized patients. STE has the potential for detecting subclinical LV systolic dysfunction, and can provide useful information regarding cardiac status in mildly symptomatic COVID-19 population.en_US
dc.identifier.doi10.1007/s10554-021-02318-9
dc.identifier.endpage2964en_US
dc.identifier.issn1569-5794
dc.identifier.issn1875-8312
dc.identifier.issue10en_US
dc.identifier.pmid34156654en_US
dc.identifier.scopus2-s2.0-85108657180en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2957en_US
dc.identifier.urihttps://doi.org/10.1007/s10554-021-02318-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11063
dc.identifier.volume37en_US
dc.identifier.wosWOS:000664390100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal Of Cardiovascular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectSpeckle Tracking Echocardiographyen_US
dc.subjectSubclinical Myocardial Dysfunctionen_US
dc.subjectGlobal Longitudinal Strainen_US
dc.titleHidden danger of COVID-19 outbreak: evaluation of subclinical myocardial dysfunction in patients with mild symptomsen_US
dc.typeArticleen_US

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