Breast Cancer Among Patients Below Age 40: Clinicopathological Features and Survival Results

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dc.contributor.authorYavuz, Berrin Benli
dc.contributor.authorAktan, Meryem
dc.contributor.authorKanyilmaz, Gul
dc.date.accessioned2024-02-23T14:40:52Z
dc.date.available2024-02-23T14:40:52Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractAmong young women breast cancer exhibits quite a heterogenous, quite agressive and complex biology. The purpose of this study is to describe clinicopathological features that affect survival ratio among breast cancer women below age-40. 803 patients having received adjuvant radiotherapy were retrospectively analyzed. Patients were categorized under two groups: age <= 40 and age > 40. Treatments and clinicopathological features were analyzed. 19.4% (156) of 803 patients were below age 40. In patient group below age 40, more neoadjuvant chemotherapy (NAC) was administered compared to the patient group above age 40 (p= 0.007) and it was detected that there were higher incidences of stage 3 disease (p= 0.011), more advanced nodal disease (N2-3) (p= 0.046) and more metastasis (p< 0.001). In conducted multivariate analysis for all age groups presence of N2-3 disease (p= 0.011) and in below age-40 group being grad 3 (p= 0.025) was found to affect overall survival (OS) negatively. In disease free survival (DFS)-focused analysis; for all age groups, receiving NAC (p= 0.001), presence of N2-3 disease (p= 0.002) and being below age 40 were found to have a negative effect; in below age-40 group presence of NAC (p= 0.013) and perineural invasion (p= 0.035); in above age-40 group receiving NAC (p= 0.023) and presence of N2-3 disease (p= 0.035) had a negative effect. Being below age 40 is an independent prognostic factor for DFS. It is suggested to conduct further studies on specific tumor biology to analyze the same group with respect to the characteristics of more aggressive tumors.en_US
dc.identifier.doi10.4999/uhod.204577
dc.identifier.endpage237en_US
dc.identifier.issn1306-133X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85097998964en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://doi.org/10.4999/uhod.204577
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16622
dc.identifier.volume30en_US
dc.identifier.wosWOS:000591659400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Canceren_US
dc.subjectYoung Ageen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titleBreast Cancer Among Patients Below Age 40: Clinicopathological Features and Survival Resultsen_US
dc.typeArticleen_US

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