Association of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risk

Basit Öğe Kaydı
dc.contributor.authorGul, Enes Elvin
dc.contributor.authorCan, Ilknur
dc.contributor.authorGuler, Ibrahim
dc.contributor.authorYesildag, Ahmet
dc.contributor.authorAbdulhalikov, Turyan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorOzdemir, Kurtulus
dc.date.accessioned2024-02-23T14:38:03Z
dc.date.available2024-02-23T14:38:03Z
dc.date.issued2012
dc.departmentNEÜen_US
dc.description.abstractPURPOSE Heart-type fatty acid binding protein (H-FABP) is a sensitive marker of myocardial injury and predictor of worse prognosis in patients with pulmonary embolism (PE). Assessment of right ventricular dysfunction and pulmonary artery obstruction index (PAOI) with computed tomography (CT) has been reported as a predictor of mortality in PE. Therefore, we aimed to assess the correlation between H-FABP and CT angiographic PAOI in PE patients at intermediate risk. MATERIALS AND METHODS Sixty-one patients (28 males; mean age, 62 +/- 17 years) with diagnosis of PE were included in this study. CT was performed in all patients, and the following parameters were evaluated: right ventricle/left ventricle ratio (RV/LV), pulmonary artery axial diameter, superior vena cava axial diameter, and PAOI determined with Qanadli score. Blood samples were assessed for H-FABP and troponin levels. Patients were followed for 30 days after discharge. RESULTS Mean PAOI was 57 +/- 18%. Eleven patients died during the follow-up period due to PE (18% mortality rate). H-FABP was positive in 21 patients (35%). There was no difference in CT parameters between patients with positive H-FABP and negative H-FABP. In addition, CT parameters were similar between patients who survived and those who did not. RV/LV ratio correlated with PAOI score. Among the biomarkers, troponin levels correlated with both RV/LV ratio and PAOI. H-FABP was an independent predictor of mortality. PAOI and RV/LV ratio did not predict 30-day mortality. CONCLUSION Although H-FABP positivity confers a bad prognosis on PE patients at intermediate risk, PAOI did not predict mortality in this group.en_US
dc.identifier.doi10.4261/1305-3825.DIR.5827-12.3
dc.identifier.endpage536en_US
dc.identifier.issn1305-3825
dc.identifier.issue6en_US
dc.identifier.pmid22991097en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage531en_US
dc.identifier.urihttps://doi.org/10.4261/1305-3825.DIR.5827-12.3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16344
dc.identifier.volume18en_US
dc.identifier.wosWOS:000310927400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Radiologyen_US
dc.relation.ispartofDiagnostic And Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Embolismen_US
dc.subjectHeart-Type Fatty Acid-Binding Proteinen_US
dc.subjectComputed Tomographyen_US
dc.subjectPulmonary Artery Obstruction Indexen_US
dc.titleAssociation of pulmonary artery obstruction index with elevated heart-type fatty acid binding protein and short-term mortality in patients with pulmonary embolism at intermediate risken_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu