Early kidney injury in immunoglobulin A vasculitis: Role of renal biomarkers

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dc.contributor.authorTure, Esra
dc.contributor.authorYazar, Abdullah
dc.contributor.authorAkin, Fatih
dc.contributor.authorTopcu, Cemile
dc.contributor.authorAydin, Arif
dc.contributor.authorBalasar, Mehmet
dc.contributor.authorAtas, Bulent
dc.date.accessioned2024-02-23T14:24:36Z
dc.date.available2024-02-23T14:24:36Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground We aimed to determine whether urine kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) can be used as early noninvasive biomarkers of kidney injury in immunoglobulin A vasculitis. Methods Patients who were diagnosed with immunoglobulin A vasculitis were included in the study. Urine samples were collected for determination of urine KIM-1 and NGAL levels. The control group consisted of age-matched healthy children. Results Sixty-one patients who were diagnosed with immunoglobulin A vasculitis were included in the study; 37.7% of these patients were determined to have renal involvement. Median KIM-1 was found to be significantly higher in the patient group (69.59 pg/mL) than the control group (40.84 pg/mL) (P = 0.001). Median NGAL was determined to be statistically significantly higher in the patient group (59.87 ng/mL) compared with the control group (44.87 ng/mL) (P = 0.013). In 23.6% of the patients without renal involvement at admission renal involvement developed within the following 6 months. When median KIM-1 and NGAL at admission of these patients were compared with the control group, they were determined to be statistically significantly higher (P = 0.001, P = 0.003). Conclusions The fact that our patients with late-term nephropathy had no hematuria and / or proteinuria and that KIM-1 and NGAL levels were determined to be high indicates that these biomarkers might be potentially reliable, noninvasive and early determinants of kidney injury.en_US
dc.description.sponsorshipNecmettin Erbakan University scientific research projects commissionen_US
dc.description.sponsorshipWe are grateful to Necmettin Erbakan University scientific research projects commission for supporting this work.en_US
dc.identifier.doi10.1111/ped.14600
dc.identifier.endpage1222en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue10en_US
dc.identifier.pmid33423326en_US
dc.identifier.scopus2-s2.0-85112786333en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1218en_US
dc.identifier.urihttps://doi.org/10.1111/ped.14600
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14028
dc.identifier.volume63en_US
dc.identifier.wosWOS:000686277300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChilden_US
dc.subjectImmunoglobulin A Vasculitisen_US
dc.subjectKidney Injury Molecule-1en_US
dc.subjectNephropathyen_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.titleEarly kidney injury in immunoglobulin A vasculitis: Role of renal biomarkersen_US
dc.typeArticleen_US

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