Cytotoxic and Genotoxic Assessment of Silicon Dioxide Nanoparticles by Allium and Comet Tests

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dc.contributor.authorLiman, Recep
dc.contributor.authorAcikbas, Yaser
dc.contributor.authorCigerci, Ibrahim Hakki
dc.contributor.authorAli, Muhammad Muddassir
dc.contributor.authorKars, Meltem Demirel
dc.date.accessioned2024-02-23T13:43:29Z
dc.date.available2024-02-23T13:43:29Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractSilicon nanoparticles gained a great interest due to its use in biomedical research. It is considered as safe and has been used in nanomedicine. But literature still states its toxicity depending upon the size and dose of silicon nanoparticles. So, current study was aimed to evaluate the cytotoxicity and genotoxicity of silicon dioxide nanoparticles -(SiO(2)NPs) by Allium anaphase-telophase and Comet tests. Characterization of -SiO(2)NPs showed the particle size as 16.12 +/- 3.07 nm. The mean diameter of -SiO(2)NPs was having range of 404.66 +/- 93.39 nm in solution. Highest total anomalies ( 18.80 +/- 0.45) were observed at 100 mu g/mL, whereas least (11.2 +/- 0.84) were observed by the 12.5 mu g/mL concentration. There was concentration-response association in increased CAs and DNA damage. The highest concentration (100 mu g/mL) of -SiO(2)NPs induced the significant DNA damage (149.67 +/- 1.15), whereas the least was observed by the negative control (2.67 +/- 0.58). The current study revealed the cytotoxic and genotoxic effects of -SiO(2)NPs on the root meristem cells of A. cepa.en_US
dc.identifier.doi10.1007/s00128-020-02783-3
dc.identifier.endpage221en_US
dc.identifier.issn0007-4861
dc.identifier.issn1432-0800
dc.identifier.issue2en_US
dc.identifier.pmid31932906en_US
dc.identifier.scopus2-s2.0-85077894072en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.1007/s00128-020-02783-3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10830
dc.identifier.volume104en_US
dc.identifier.wosWOS:000514322200009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBulletin Of Environmental Contamination And Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSilicon Dioxide Nanoparticlesen_US
dc.subjectMitotic Indexen_US
dc.subjectDna Damageen_US
dc.subjectAllium Cepaen_US
dc.titleCytotoxic and Genotoxic Assessment of Silicon Dioxide Nanoparticles by Allium and Comet Testsen_US
dc.typeArticleen_US

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