The neutrophil to lymphocyte ratio improves the positive predictive value of dobutamine stress echocardiography

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dc.contributor.authorIcli, Abdullah
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAkilli, Hakan
dc.contributor.authorAribas, Alpay
dc.contributor.authorCoskun, Mukremin
dc.contributor.authorOzer, Sumeyye Fatma
dc.contributor.authorOzdemir, Kurtulus
dc.date.accessioned2024-02-23T14:45:59Z
dc.date.available2024-02-23T14:45:59Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractThe neutrophil to lymphocyte ratio (NLR) predicts cardiovascular events. The aim of this study was to determine whether NLR improved the positive predictive value (PPV) of dobutamine stress echocardiography (DSE) in patients with stable coronary artery disease (CAD). We conducted a retrospective review of laboratory and DSE data from the medical records of 1,012 patients who were divided into two groups according to the presence of ischemia and further subdivided into three groups according to the extent of ischemia (nonischemic segments, 1-3 ischemic segments, or > 3 ischemic segments). NLRs were compared among these groups. NLRs increased in patients with ischemia and correlated with the number of ischemic segments (P < 0.001). The optimal cutoff value of NLR determined using receiver operating characteristic analysis was > 2.04, and the diagnostic value of NLR for discriminating patients with >= 50% coronary stenosis in at least one of the coronary arteries from those without significant CAD was high [area under the curve (AUC) = 0.671, standard error = 0.052, P < 0.001, 95% confidence interval (CI) = 0.569-0.773)]. An NLR cutoff value of > 2.04 predicted CAD presence with significant stenosis (62.10% sensitivity and 64.10% specificity). PPV of DSE for a significant coronary artery lesion identified using coronary angiography was 73.8% (95% CI = 75.1-88.5, P < 0.001, AUC = 0.818). On including a cut-off value of > 2.04 for NLR in this multivariable predictive model, the AUC value slightly increased to 0.905 (95% CI = 85.4-95.6) and PPV of DSE increased from 73.8% to 92.6%. NLR improved PPV of DSE for patients with stable CAD.en_US
dc.identifier.endpage15629en_US
dc.identifier.issn1940-5901
dc.identifier.issue9en_US
dc.identifier.pmid26629056en_US
dc.identifier.scopus2-s2.0-84946545223en_US
dc.identifier.startpage15621en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17730
dc.identifier.volume8en_US
dc.identifier.wosWOS:000367911200069en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDobutamine Stress Echocardiographyen_US
dc.subjectMyocardial Ischemiaen_US
dc.subjectNeutrophil To Lymphocyte Ratioen_US
dc.subjectStable Coronary Artery Diseaseen_US
dc.titleThe neutrophil to lymphocyte ratio improves the positive predictive value of dobutamine stress echocardiographyen_US
dc.typeArticleen_US

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