The effects of local and intraperitoneal zinc treatments on maxillofacial fracture healing in rabbits

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dc.contributor.authorAzgin, Isa
dc.contributor.authorArbag, Hamdi
dc.contributor.authorEryilmaz, Mehmet Akif
dc.contributor.authorCelik, Zeliha Esin
dc.date.accessioned2024-02-23T14:12:39Z
dc.date.available2024-02-23T14:12:39Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjective: This study aimed to determine whether administration of topical and intraperitoneal zinc for maxillofacial fractures has any impact on the bone healing process. Material and method: Thirty-two New Zealand rabbits were randomly assigned to four groups of eight each. The first group was the control group; fracture lines were fixed using titanium microplates and no medication was administered. The second group received fixations using zinc-coated titanium microplates. A single dose of 3 mg/kg zinc was administered intraperitoneally to the third group following fixations with titanium microplates. A single dose of 3 mg/kg zinc was administered intraperitoneally to the fourth group following fixations with zinc-coated titanium microplates. Zinc coating on to the titanium microplates was achieved using the physical vapor deposition technique. A fracture line was created in the nasal bones of all subjects and fixed with five-hole flat microplates and three 5-mm micro screws. All work groups were sacrificed at the end of the sixth week. Results: Histological examination showed that the number of osteoblasts were significantly higher in zinc-coated group (Group 2) than zinc uncoated, control group (Group 1), (415.6 +/- 46.7 vs 366.3 +/- 11.8) (p < 0.001). It was observed that intraperitoneal zinc treatment alone (Group 3) did not significantly increase in the osteoblast count compared to zinc un-coated group (Group 1), (390.6 +/- 83.2 vs 366.3 +/- 11.8), (p = 0.341). The immunoreactivity scores for IGF-1 were significantly higher in the zinccoated group compared to control group (Group 2 vs 1), (9.3 +/- 2.8 vs 3.7 +/- 1.9) (p < 0.05). It was observed that intraperitoneal zinc treatment did not cause a significant difference in the aspect of IGF-1 for zinc-coated groups (Group 2 vs 4) (9.3 +/- 2.8 vs 9.6 +/- 2.2) (p = 0.791). The difference in the immunoreactivity score among whole groups for TGF-beta was not statistically significant (Group 1 vs 2, 3.2 +/- 1.7 vs 4.4 2.3, p = 0.256; Group 1 vs 3, 3.2 1.7 vs 3.8 2.8, p = 0.524; Group 1 vs 4, 3.2 1.7 vs 2.8 1.3, p = 0.717; Group 2 vs 3, 4.4 2.3, vs 3.8 2.8, p = 0.610; Group 2 vs 4, 4.4 2.3, vs 2.8 + 1.3, p = 0.124; Group 3 vs 4, 3.8 2.8, vs 2.8 + 1.3, p = 0.311). Conclusion: The local use of titanium microplates coated with zinc by PVD technique was found effective for fracture healing. Zinc coating of titanium microplates used in fracture treatment can accelerate fracture healing. It may be concluded that clinical studies should be performed now in order to explore if comparable results can be achieved in humans. (C) 2020 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipNecmettin Erbakan University, Medical Faculty [121518016]en_US
dc.description.sponsorshipThis work was supported by the Necmettin Erbakan University, Medical Faculty [Grant Number: 121518016].en_US
dc.identifier.doi10.1016/j.jcms.2020.01.013
dc.identifier.endpage267en_US
dc.identifier.issn1010-5182
dc.identifier.issn1878-4119
dc.identifier.issue3en_US
dc.identifier.pmid32046897en_US
dc.identifier.scopus2-s2.0-85079170178en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcms.2020.01.013
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12143
dc.identifier.volume48en_US
dc.identifier.wosWOS:000519968900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofJournal Of Cranio-Maxillofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMaxillofacial Traumaen_US
dc.subjectFracture Healingen_US
dc.subjectZincen_US
dc.subjectIgf-1en_US
dc.subjectTgf-Betaen_US
dc.titleThe effects of local and intraperitoneal zinc treatments on maxillofacial fracture healing in rabbitsen_US
dc.typeArticleen_US

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