The effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitro

Basit Öğe Kaydı
dc.contributor.authorGormus, Zulfikare Isik Solak
dc.contributor.authorVidin, Tuba
dc.contributor.authorKoca, Raviye Ozen
dc.contributor.authorSolak, Hatice
dc.contributor.authorUslu, Esra Fidan
dc.date.accessioned2024-02-23T14:31:38Z
dc.date.available2024-02-23T14:31:38Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective: This study aimed to determine the potential effects of three popular antidepressants: agomelatine, fluoxetine, and sertraline on in vitro rat bladder contraction responses, and to investigate their contribution to overactive bladder syndrome. Method: Thirty-two adult male Wistar albino rats, weighing between 300-350 g, were randomly divided into four groups (Control, Agomelatine, Fluoxetine, Sertraline). After cervical dislocation, the bladders were promptly removed, cut into 3-4-millimeter strips, and suspended in an isolated organ bath at a tension of 1 gram. Contractions were induced by acetylcholine (ACh) at a concentration of 10(-5) M. Cumulative doses of agomelatine, fluoxetine, and sertraline (ranging from 10(-8) to 10(-3) M) were administered to the organ bath chambers. The least squares means were compared using the Tukey-Kramer post-hoc test to compare the tension values of the groups at different time points.Results: The inhibition of rat bladder contractions was statistically significant at agomelatine doses of 10(-7) M (p=0.0413), 10(-6) M (p=0.033), 10(-5)M (p=0.003), and 10(-4) M (p<0.001), with a statistically significant recontraction response noticed after the agomelatine dose of 10(-3) M (p<0.001). Cumulative fluoxetine doses at 10(-7) M (p=0.0182), 10(-6) M (p=0.0012), and 10(-5), 10(-4), 10(-3) M (all at p<0.001), along with sertraline doses at 10(-5) M (p=0.0096), 10(-4) M (p=0.001), and 10(-3) M (p<0.001), also significantly inhibited contraction. Conclusion: Agomelatine, fluoxetine, and sertraline were found to exhibit inhibitory effects on bladder contraction in a dose-dependent manner.en_US
dc.description.sponsorshipScientific Investigations Projects Coordinatorship of Necmettin Erbakan University [181318015]en_US
dc.description.sponsorshipFinancial Disclosure: The study was supported by the Scientific Investigations Projects Coordinatorship of Necmettin Erbakan University (SIPC Project Number: 181318015) .en_US
dc.identifier.doi10.14744/DAJPNS.2023.00218
dc.identifier.endpage156en_US
dc.identifier.issn1018-8681
dc.identifier.issn1309-5749
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85175081891en_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.14744/DAJPNS.2023.00218
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15269
dc.identifier.volume36en_US
dc.identifier.wosWOS:001078294400005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofDusunen Adam-Journal Of Psychiatry And Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOveractive Bladderen_US
dc.subjectContractionen_US
dc.subjectAgomelatineen_US
dc.subjectFluoxetineen_US
dc.subjectSertralineen_US
dc.titleThe effects of agomelatine, fluoxetine, and sertraline on rat bladder contraction in vitroen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu