The effect of fundus resection on weight loss and ghrelin levels in rats

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dc.contributor.authorOkus, A.
dc.contributor.authorSevinc, B.
dc.contributor.authorKarahan, O.
dc.contributor.authorAy, S.
dc.contributor.authorCivcik, S.
dc.date.accessioned2024-02-23T14:37:59Z
dc.date.available2024-02-23T14:37:59Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Ghrelin is a 28-amino acid peptide that is isolated mainly from the oxyntic glands of the stomach, especially fundus. Ghrelin administration, either centrally or peripherally, increases food intake and body weight in both rodents and humans. This study evaluates the effects of fundus resection and sclerosing agent injection on ghrelin level and weight loss. MATERIAL AND METHODS: Thirty rats were divided into three groups. In group 1, NaCl was injected into the submucosal space at the gastric fundus while in Group 2, a sclerosing agent was injected into the latter site. In group 3, gastric fundus was resected. Ghrelin levels and weight were recorded. RESULTS: In group 1, rats continued gaining weight and ghrelin levels stayed stable. In group 2, rats' weight and ghrelin levels stayed stable and in group 3, while weight stayed stable, ghrelin levels decreased significantly. CONCLUSION: In rats, the resection of fundus stabilizes weight gain and decreases ghrelin levels. However, in sclerotherapy, although weight gain was stabilized, there was no decrease in ghrelin levels. In humans, the effect of fundus resection on weight gain can usher in a new era of investigation (Tab. 2, Ref. 16). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2016_070
dc.identifier.endpage357en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue6en_US
dc.identifier.pmid27546369en_US
dc.identifier.scopus2-s2.0-85014842788en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_070
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16318
dc.identifier.volume117en_US
dc.identifier.wosWOS:000378300700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFundus Resectionen_US
dc.subjectSclerotherapyen_US
dc.subjectGhrelinen_US
dc.titleThe effect of fundus resection on weight loss and ghrelin levels in ratsen_US
dc.typeArticleen_US

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