Effects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic review

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dc.contributor.authorFaghfoori, Zeinab
dc.contributor.authorJavadivala, Zeinab
dc.contributor.authorKhalili, Yeganeh
dc.contributor.authorMahdavi, Aida Malek
dc.date.accessioned2024-02-23T14:20:17Z
dc.date.available2024-02-23T14:20:17Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackgroundAdjuvant therapies especially medicinal plants have gained lots of attention nowadays and have been consumed all over the world for treating different diseases particularly rheumatoid arthritis (RA). Recent animal studies have indicated the benefits of fenugreek in RA and indicate that it may be a therapeutic candidate in RA; nonetheless, no systematic review is available about fenugreek and RA. This paper systematically reviewed the existing studies about fenugreek and RA and plausible mechanisms.MethodsDatabases including PubMed, Scopus, Web of Science, ProQuest, and the search engine Google Scholar were searched until May 2022 and search alerts were used to receive studies issued after the primary search. There was no restriction in time and/or language. No human and in vitro research was detected; thus, animal investigations were considered. Also, the citations or references of studies were searched for potential studies. Book chapters, review papers, and grey literature (e.g. conference abstracts, dissertations, and patents) were not included.ResultsFinally, 11 studies were entered in this systematic review. Animal investigations showed that fenugreek had favorable effects in RA and could control this disease via attenuating inflammation, suppressing oxidative stress, and displaying anti-arthritic activity.ConclusionCurrent review provides potent evidences about the efficacy of fenugreek in RA and elucidates the significance of more clinical investigations.en_US
dc.description.sponsorshipFood Safety Research Center (salt) of Semnan University of Medical Sciences and Health Services, Semnan, Iran [A-10-377-14]en_US
dc.description.sponsorshipThis work was supported by the Food Safety Research Center (salt) of Semnan University of Medical Sciences and Health Services, Semnan, Iran (Grant No. A-10-377-14).en_US
dc.identifier.doi10.1080/08923973.2023.2202298
dc.identifier.endpage634en_US
dc.identifier.issn0892-3973
dc.identifier.issn1532-2513
dc.identifier.issue5en_US
dc.identifier.pmid37039783en_US
dc.identifier.scopus2-s2.0-85153473631en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage626en_US
dc.identifier.urihttps://doi.org/10.1080/08923973.2023.2202298
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13100
dc.identifier.volume45en_US
dc.identifier.wosWOS:000972783500001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofImmunopharmacology And Immunotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrigonellaen_US
dc.subjectArthritisen_US
dc.subjectRheumatoiden_US
dc.subjectSystematic Reviewen_US
dc.titleEffects of Trigonella foenum graecum (fenugreek) on rheumatoid arthritis: a systematic reviewen_US
dc.typeReview Articleen_US

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