Prognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemia

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dc.contributor.authorDemircioglu, Sinan
dc.contributor.authorEkinci, Omer
dc.contributor.authorDogan, Ali
dc.contributor.authorUlas, Turgay
dc.date.accessioned2024-02-23T14:29:27Z
dc.date.available2024-02-23T14:29:27Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractObjective: Chromosomal abnormalities are one of the most important prognostic factors in acute myeloid leukemia (AML). However, not all patients may have such informative chromosomal abnormalities. Although there are many studies on the prognostic value of immunophenotyping in AML, it is still not used as a prognostic marker. In this study, we aimed to investigate the effects of CD13, CD33, CD34, CD117, MPO and HLADR expressions on prognosis of non-acute promyelocytic leukemia AML.Methods: One hundred thirteen patients diagnosed as having non -acute promyelocytic leukemia AML and followed up between 2010 and 2018 were included in this study. The associations of CD13, CD33, CD34, CD117, MPO and HLA DR expressions with chemotherapy response, progression free survival (PFS) and overall survival (OS) were statistically analyzed.Results: It was seen that response to chemotherapy was achieved in 67.3% of the patients. Median PFS duration was 9 months and median OS duration was found as 13 months. Of the immunophenotypic characteristics, only MPO expression was determined to be an independent risk factor for PFS and OS.Conclusion: Immunophenotypic features may be helpful in the diagnosis of AML as well as give an idea about prognosis. In this study, MPO expression was shown to be an independent risk factor for PFS and OS in our own patient population.en_US
dc.identifier.doi10.14235/bas.galenos.2021.5875
dc.identifier.endpage408en_US
dc.identifier.issn2148-2373
dc.identifier.issue4en_US
dc.identifier.startpage402en_US
dc.identifier.urihttps://doi.org/10.14235/bas.galenos.2021.5875
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14711
dc.identifier.volume10en_US
dc.identifier.wosWOS:000849963300003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBezmialem Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectImmunophenotypingen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.titlePrognostic Significance of Flow Cytometric Immunophenotyping in Patients with Acute Myeloid Leukemiaen_US
dc.typeArticleen_US

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