Benzodithiophene bearing conjugated polymer-based surface anchoring for sensitive electrochemical glucose detection

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dc.contributor.authorBulut, Umut
dc.contributor.authorSayin, Vuslat Oyku
dc.contributor.authorCevher, Sevki Can
dc.contributor.authorCirpan, Ali
dc.contributor.authorSoylemez, Saniye
dc.date.accessioned2024-02-23T14:34:41Z
dc.date.available2024-02-23T14:34:41Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAn amino-functionalized, conjugated polymer (P(BDBT)) modified glassy carbon electrode (GCE) was employed as an immobilization platform for glucose oxidase (GOx) enzyme to assemble a novel glucose biosensor. Amino groups available on the polymer backbone served as bioconjugation sites for GOx via glutaraldehyde (GA). The biosensor response to the reduction in oxygen amount because of the enzyme reaction was monitored at ???0.7 V potential versus Ag/AgCl. The biosensor displayed a broad linear range between 0.1???1.0 mM glucose with a detection limit of 0.17 mM. The values of the apparent Michaelis-Menten constant (KMapp) and sensitivity were determined as 1.74 mM, and 28.17 ??A/(mM??cm2), respectively. GOx immobilized P(BDBT) film displayed high stability, selectivity, and reproducibility. Cyclic voltammetry (CV) and Scanning electron microscopy (SEM) techniques were utilized for the characterization of surface modifications. The fabricated biosensor was adept at determining the amount of glucose in a commercial beverage. The simple electrochemical method for the construction of P(BDBT)/GOx biosensors could pave the way to new perspectives in developing profitable biosensors.en_US
dc.identifier.doi10.3144/expresspolymlett.2022.74
dc.identifier.endpage1021en_US
dc.identifier.issn1788-618X
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85135375711en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1012en_US
dc.identifier.urihttps://doi.org/10.3144/expresspolymlett.2022.74
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15710
dc.identifier.volume16en_US
dc.identifier.wosWOS:000842465000002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBudapest Univ Technol & Econen_US
dc.relation.ispartofExpress Polymer Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMolecular Engineeringen_US
dc.subjectAmperometric Glucose Biosensoren_US
dc.subjectGlucose Oxidaseen_US
dc.subjectEnzyme Immobilizationen_US
dc.subjectConjugated Polymersen_US
dc.titleBenzodithiophene bearing conjugated polymer-based surface anchoring for sensitive electrochemical glucose detectionen_US
dc.typeArticleen_US

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