The potential application of gold-apoferritin nanocages conjugated with 2-amino-2-deoxy-glucose for imaging of breast cancer cells

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dc.contributor.authorAslan, Tugba Nur
dc.contributor.authorAsik, Elif
dc.contributor.authorGuray, N. Tulin
dc.contributor.authorVolkan, Murvet
dc.date.accessioned2024-02-23T13:55:53Z
dc.date.available2024-02-23T13:55:53Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractDevelopment of biocompatible and multifunctional nanoprobes for tumor targeting, imaging, and therapy still remains a great challenge. Herein, gold nanoparticles (AuNPs) were synthesized in the cavity of horse spleen apoferritin protein (HoSAF) and protein surface was labeled with 2-amino-2-deoxy-glucose (2DG) as a cell surface glucose transport protein specific targeting probe to study the feasibility of its usage as a computer tomography (CT) contrast agent with tumor targeting capability through in vitro experiments. 2DG conjugated and gold-loaded apoferritin (Au-HoSAF-2DG) nanoparticles (NPs) showed selective targeting for human breast adenocarcinoma (MCF-7) cells when compared to normal breast (MCF-10A) cells. This AuNP-based imaging agent was found to be non-cytotoxic in a given concentration range with an apoptotic effect upon longer exposure times towards MCF-7 cells, while MCF-10A cells were affected less. This selective cell death would also be useful for further cancer treatments with the ability of X-ray attenuation in in vitro X-ray and computed tomography (CT) imaging. [GRAPHICS] .en_US
dc.description.sponsorshipNecmettin Erbakan University Research Funding Center (BAP-Project) [191215003]en_US
dc.description.sponsorshipThis study was funded by Necmettin Erbakan University Research Funding Center (BAP-Project No: 191215003).en_US
dc.identifier.doi10.1007/s00775-020-01830-y
dc.identifier.endpage1152en_US
dc.identifier.issn0949-8257
dc.identifier.issn1432-1327
dc.identifier.issue8en_US
dc.identifier.pmid33128617en_US
dc.identifier.scopus2-s2.0-85094678568en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1139en_US
dc.identifier.urihttps://doi.org/10.1007/s00775-020-01830-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11000
dc.identifier.volume25en_US
dc.identifier.wosWOS:000583142100001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Biological Inorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoferritinen_US
dc.subjectIn Vitro Imagingen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectX-Ray Computed Tomographyen_US
dc.titleThe potential application of gold-apoferritin nanocages conjugated with 2-amino-2-deoxy-glucose for imaging of breast cancer cellsen_US
dc.typeArticleen_US

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