A novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway

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dc.contributor.authorYesilkaya, Umit Haluk
dc.contributor.authorGica, Sakir
dc.contributor.authorTasdemir, Busra Guney
dc.contributor.authorMenekseoglu, Pelin Ozkara
dc.contributor.authorCirakli, Zeynep
dc.contributor.authorKaramustafalioglu, Nesrin
dc.date.accessioned2024-02-23T14:13:02Z
dc.date.available2024-02-23T14:13:02Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: Many hypotheses have put forward to better understand the pathogenesis of schizophrenia (SZ), such as synaptic pruning, stress-diathesis, neurodevelopment, neurodegeneration and neurotransmitter hypothesis; nonetheless, this pathogenesis still remains a mystery. The current study was designed with the hypothesis that impairment of a balance between pro-BDNF/mature BDNF and their receptors p75NTRK/TrkB may cause synaptic pruning in the pathogenesis of psychotic disorders. Methods: Sixty-five drug-naive patients with first-episode psychosis (FEP) who applied to outpatient clinics and were diagnosed according to DSM-5 as well as 65 healthy controls (HC) were included in the study. Symptoms at the time of evaluation were assessed with the PANSS scale by an experienced psychiatrist. Blood samples were collected from all participants to determine BDNF, pro-BDNF, TrkB and p75NTR, PAI1, tPA, ACTH and cortisol levels. Results: Mature BDNF, TrkB and PAI-1, tPA levels were significantly lower while the levels of ACTH and cortisol were significantly higher in FEP patients compared to HC. No significant difference was found in pro-BDNF and p75NTR levels between the two independent groups. The pro-BDNF/mature BDNF and the p75NTR/TrkB ratios were significantly higher in FEP patients compared to HC. Moreover, the pro-BDNF/mature BDNF and the p75NTR/TrkB ratios were found to be significantly associated with the pathogenesis of SZ in a hierarchical regression model. Discussion: Imbalance between neurotrophic and apoptotic proteins such as pro-BDNF/mature BDNF and p75NTR/TrkB may be take part pathogenesis of synaptic pruning in psychotic disorders.en_US
dc.identifier.doi10.1016/j.jpsychires.2021.07.056
dc.identifier.endpage166en_US
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid34359010en_US
dc.identifier.scopus2-s2.0-85111692540en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2021.07.056
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12265
dc.identifier.volume142en_US
dc.identifier.wosWOS:000694743000021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectBdnfen_US
dc.subjectNeurotrophinen_US
dc.subjectProbdnfen_US
dc.subjectSchizophreniaen_US
dc.subjectSynaptic Pruningen_US
dc.titleA novel commentary: Investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathwayen_US
dc.typeArticleen_US

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