Evaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Cancer

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dc.contributor.authorBakbak, Berat Berrin Gencoglu
dc.contributor.authorIlhan, Tolgay Tuyan
dc.contributor.authorPekin, Aybike
dc.contributor.authorKerimoglu, Ozlem Secilmis
dc.contributor.authorYilmaz, Setenay Arzu
dc.contributor.authorKebapcilar, Aysegul
dc.contributor.authorDogan, Nasuh Utku
dc.date.accessioned2024-02-23T14:29:39Z
dc.date.available2024-02-23T14:29:39Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractObjectives: Clinical evidence supports the association of toll-like receptor (TLR) with abnormal cell proliferation and cancer. In this study, we investigated the expression of TLRs 2, 4, 5, and 6 in healthy endometrium and endometrium cancer to study the relationship of these receptors' expression with carcinogenesis. Methods: Patients who had undergone a hysterectomy owing to endometrium cancer (group 1, 66 patients), endometrial hyperplasia (group 2, 14 patients), and other reasons besides endometrium cancer (group 3, 20 patients as controls) were included. The cases in the first group were classified by histological type of the cancer, stage, grade, and size of the tumor. In all the cases, expressions of TLRs 2, 4, 5, and 6 were assessed, and the relationship of these receptors with clinicopathologic signs was analyzed. For immunohistochemical staining, nuclear and cytoplasmic stainings were considered positive. A Chi-squared test was used to assess the correlation of the groups. A p<0.05 was considered significant. Results: The mean ages of patients in groups 1, 2, and 3 were 59.8 (range 33-83), 48.3 (range 40-59), and 53.4 (range 38-84) years, respectively. All types of TLRs were highly expressed in both types of endometrium cancer (groups 1 and 2). TLR expression was observed with a ratio of 87.9% in group 1, 100% in group 2, and 35% in group 3. There was a statistically significant association of TLR 2 among the three groups (p=0.000). TLR 6 expression in both group 1 and group 2 was significantly higher than that in the control group (p=0.000, p=0.000, respectively). In addition, TLR 6 was higher in cases with late-stage cancer (p=0.033). Regarding tumor grade and the size of the tumor, no association was found between TLR 2 and TLR 6. Conclusion: TLR 2 and TLR 6 were significantly more expressed in cases with endometrium cancer and endometrial hyperplasia. In addition, the presence of TLR 6 may indicate the presence of late-stage endometrial cancer.en_US
dc.identifier.doi10.14744/SEMB.2018.63325
dc.identifier.endpage200en_US
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue3en_US
dc.identifier.pmid32595398en_US
dc.identifier.startpage196en_US
dc.identifier.urihttps://doi.org/10.14744/SEMB.2018.63325
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14801
dc.identifier.volume52en_US
dc.identifier.wosWOS:000454997800008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherYerkure Tanitim Yayincilik Hizmetleri Asen_US
dc.relation.ispartofMedical Bulletin Of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndometriumen_US
dc.subjectEndometrial Canceren_US
dc.subjectToll-Like Receptoren_US
dc.subjectTumor Microenvironmenten_US
dc.titleEvaluation of Toll-Like Receptor Expression with Clinicopathologic Variables in Endometrium Canceren_US
dc.typeArticleen_US

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